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    H2-DMa histocompatibility 2, class II, locus DMa [ Mus musculus (house mouse) ]

    Gene ID: 14998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2-DMaprovided by MGI
    Official Full Name
    histocompatibility 2, class II, locus DMaprovided by MGI
    Primary source
    MGI:MGI:95921
    See related
    Ensembl:ENSMUSG00000037649 AllianceGenome:MGI:95921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2Ma; H2-Ma
    Summary
    Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in positive regulation of germinal center formation and positive regulation of humoral immune response. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive thymic T cell selection. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 22.7), large intestine adult (RPKM 15.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See H2-DMa in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34338667..34358075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34119693..34139101)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene histocompatibility 2, class II, locus Mb2 Neighboring gene STARR-positive B cell enhancer ABC_E7523 Neighboring gene histocompatibility 2, class II, locus Mb1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed. Wolf PR, et al. Eur J Immunol, 1998 Sep. PMID 9754549
    2. Unexpected reactivities of T cells selected by a single MHC-peptide ligand. Singh N, et al. J Immunol, 1999 Oct 1. PMID 10490950
    3. Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome. Tilahun AY, et al. Am J Pathol, 2011 Jun. PMID 21641398, Free PMC Article
    4. Expression and function of HLA-DR3 and DQ8 in transgenic mice lacking functional H2-M. Rajagopalan G, et al. Tissue Antigens, 2003 Aug. PMID 12889995
    5. Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice. Viret C, et al. J Immunol, 2000 May 1. PMID 10779766

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class II protein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide antigen assembly with MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class II protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    class II histocompatibility antigen, M alpha chain
    Names
    H2-M alpha
    MHC class II antigen DMa
    histocompatibility 2, class II, locus Ma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360530.1 → NP_001347459.1  class II histocompatibility antigen, M alpha chain precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR974422, CR974462
      Consensus CDS
      CCDS37579.1
      UniProtKB/TrEMBL
      Q31621, Q95606, Q9QWV0
      Conserved Domains (2) summary
      smart00920
      Location:41 → 123
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:127 → 218
      Ig; Immunoglobulin domain

    2. NM_001424788.1 → NP_001411717.1  class II histocompatibility antigen, M alpha chain precursor

      Status: VALIDATED

      Source sequence(s)
      CR974422, CR974462
      UniProtKB/TrEMBL
      Q31621, Q95606, Q9QWV0

    3. NM_010386.4 → NP_034516.3  class II histocompatibility antigen, M alpha chain precursor

      See identical proteins and their annotated locations for NP_034516.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK146950, CR974422
      Consensus CDS
      CCDS37579.1
      UniProtKB/TrEMBL
      Q31621, Q95606, Q9QWV0
      Related
      ENSMUSP00000037088.10, ENSMUST00000042121.11
      Conserved Domains (2) summary
      smart00920
      Location:41 → 123
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:127 → 218
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34338667..34358075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249508.1 → XP_030105368.1  class II histocompatibility antigen, M alpha chain isoform X1

      UniProtKB/TrEMBL
      Q31621, Q95606, Q9QWV0
      Conserved Domains (2) summary
      smart00920
      Location:41 → 123
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:127 → 218
      Ig; Immunoglobulin domain

    2. XM_017317260.2 → XP_017172749.1  class II histocompatibility antigen, M alpha chain isoform X1

      UniProtKB/TrEMBL
      Q31621, Q95606, Q9QWV0
      Conserved Domains (2) summary
      smart00920
      Location:41 → 123
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:127 → 218
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28078.1 GenPept UniProtKB/Swiss-Prot:P28078

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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