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    Tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [ Mus musculus (house mouse) ]

    Gene ID: 21927, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tnfaip1provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 1 (endothelial)provided by MGI
    Primary source
    MGI:MGI:104961
    See related
    Ensembl:ENSMUSG00000017615 AllianceGenome:MGI:104961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edp1; Edp-1; Tnfip1; Bacurd2
    Summary
    Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; positive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 35.5), large intestine adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnfaip1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78413676..78427122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78522850..78536270, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene polymerase (DNA-directed), delta interacting protein 2 Neighboring gene intraflagellar transport 20 Neighboring gene transmembrane protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E3979

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding  
    enables cyclin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables small GTPase binding  
    enables small GTPase binding  
    contributes_to ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in cell migration  
    involved_in cell migration  
    involved_in immune response  
    involved_in negative regulation of Rho protein signal transduction  
    involved_in negative regulation of Rho protein signal transduction  
    involved_in negative regulation of Rho protein signal transduction  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA replication  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein homooligomerization  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in stress fiber assembly  
    involved_in stress fiber assembly  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex  
    part_of Cul3-RING ubiquitin ligase complex  
    part_of Cul3-RING ubiquitin ligase complex  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endosome  
    located_in endosome  
    located_in nucleus  

    General protein information

    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Names
    BTB/POZ domain-containing protein TNFAIP1
    tumor necrosis factor induced protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159392.1NP_001152864.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_001152864.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK034305, AK147809, AK168805, BY060883, CB205355
      Consensus CDS
      CCDS25110.1
      UniProtKB/Swiss-Prot
      O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
      Related
      ENSMUSP00000103912.3, ENSMUST00000108277.3
      Conserved Domains (2) summary
      smart00225
      Location:29127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:30120
      BTB_2; BTB/POZ domain
    2. NM_009395.4NP_033421.3  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_033421.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK034305, AK147809, AK168805, BY329500, CB205355
      Consensus CDS
      CCDS25110.1
      UniProtKB/Swiss-Prot
      O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
      Related
      ENSMUSP00000017759.3, ENSMUST00000017759.9
      Conserved Domains (2) summary
      smart00225
      Location:29127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:30120
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78413676..78427122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245918.2XP_030101778.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:125
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    2. XM_030245919.2XP_030101779.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:125
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
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