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    Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [ Mus musculus (house mouse) ]

    Gene ID: 21762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmd2provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 2provided by MGI
    Primary source
    MGI:MGI:1096584
    See related
    Ensembl:ENSMUSG00000006998 AllianceGenome:MGI:1096584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tex190; TEG-190; 9430095H01Rik
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including central nervous system and retina. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 102.9), CNS E11.5 (RPKM 75.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmd2 in Genome Data Viewer
    Location:
    16 A3; 16 12.49 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20469872..20482164)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20651122..20663414)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene endothelin converting enzyme 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
    2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
    3. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
    4. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Stanhill A, et al. Mol Cell, 2006 Sep 15. PMID 16973439
    5. Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Xing L, et al. Cell Rep, 2023 Jul 25. PMID 37389991, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in proteasome storage granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 2
    Names
    26S proteasome regulatory subunit RPN1
    26S proteasome regulatory subunit S2
    26S proteasome subunit p97
    testis expressed gene 190

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134101.2 → NP_598862.1  26S proteasome non-ATPase regulatory subunit 2

      See identical proteins and their annotated locations for NP_598862.1

      Status: VALIDATED

      Description
      Transcript Variant: This transcript (1) is the protein-coding transcript variant.
      Source sequence(s)
      BC024830, BY307723
      Consensus CDS
      CCDS28053.1
      UniProtKB/Swiss-Prot
      Q8VDM4
      UniProtKB/TrEMBL
      Q3TI61, Q3TKV1, Q3TW71, Q3TXV1
      Related
      ENSMUSP00000007212.9, ENSMUST00000007212.9
      Conserved Domains (1) summary
      COG5110
      Location:7 → 906
      RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_027485.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a codon exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC024830, BC033325, BY307723
      Related
      ENSMUST00000172207.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20469872..20482164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249039.1 → XP_030104899.1  26S proteasome non-ATPase regulatory subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VDM4
      UniProtKB/TrEMBL
      Q3TI61, Q3TKV1, Q3TW71, Q3TXV1
      Conserved Domains (1) summary
      COG5110
      Location:7 → 906
      RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDM4.1 GenPept UniProtKB/Swiss-Prot:Q8VDM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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