Bst1 bone marrow stromal cell antigen 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bst1provided by MGI
Official Full Name: bone marrow stromal cell antigen 1provided by MGI
Primary source: MGI:MGI:105370
See related: Ensembl:ENSMUSG00000029082 AllianceGenome:MGI:105370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bp3; BP-3; Ly65; Bsta1; CD157; 114/A10; A530073F09
Summary: Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of calcium-mediated signaling; and regulation of neutrophil chemotaxis. Predicted to be located in uropod. Predicted to be active in plasma membrane. Is expressed in cerebellum; forebrain; and spleen white pulp. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 27.4), duodenum adult (RPKM 25.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 23.84 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (43976235..44000810)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (43818880..43843468)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury.
Title: Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury.
Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.
Title: Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.
Results indicate a neuronal role for CD157 in addition to its known functions in the digestive and immune systems. Less abundant expression of CD157 in the adult brain raises questions about the common features associated with the late onset of Parkinson's disease. Because CD157 is expressed abundantly in the embryonic brain, it may be involved in the processes of neuronal development that relate to psychiatric disorders.
Title: An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease.
Title: Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.
Two ADPR cyclase family members (CD38 and CD157) are present in renal preglomerular resistance arterioles, and CD38 participation in acute vascular responses to vasoconstrictors is important in renal microcirculation.
Title: Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine.
CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review]
Title: CD157, the Janus of CD38 but with a unique personality.
TNF but not RANK-L led to the sustained upregulation of both CD38 and CD157 as demonstrated by real-time PCR and flow cytometry
Title: Selective upregulation of the ADP-ribosyl cyclases CD38 and CD157 by TNF but not by RANK-L reveals differences in downstream signaling.
results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis
Title: Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Markers

Bst1 (e-PCR), detects polymorphism
- UniSTS:166207

D31788 (e-PCR)
- UniSTS:179162

D5Jcs608 (e-PCR), detects polymorphism
- UniSTS:507901

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	ISO Inferred from Sequence Orthology more info
enables phosphorus-oxygen lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Names: ADP-ribosyl cyclase 2; BP-3 alloantigen; BST-1; antigen BP3; bone marrow stromal antigen 1; cADPr hydrolase 2; cyclic ADP-ribose hydrolase 2; leukocyte antigen 65; ly-65

NP_033893.2

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.