Trpm4 transient receptor potential cation channel, subfamily M, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpm4provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily M, member 4provided by MGI
Primary source: MGI:MGI:1915917
See related: Ensembl:ENSMUSG00000038260 AllianceGenome:MGI:1915917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LTRPC4; TRPM4B; LTrpC-4; 1110030C19Rik
Summary: Enables ATP binding activity; calcium channel activity; and calcium-activated cation channel activity. Involved in several processes, including cellular response to ATP; dendritic cell chemotaxis; and protein homotetramerization. Acts upstream of or within calcium ion transport. Located in plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 55.6), duodenum adult (RPKM 35.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.24 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44952579..44983495, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45303155..45334071, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
Title: Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
In Silico Electrophysiological Investigation of Transient Receptor Potential Melastatin-4 Ion Channel Biophysics to Study Detrusor Overactivity.
Title: In Silico Electrophysiological Investigation of Transient Receptor Potential Melastatin-4 Ion Channel Biophysics to Study Detrusor Overactivity.
Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias.
Title: Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias.
TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose.
Title: TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose.
Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis.
Title: Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis.
Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice.
Title: Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice.
TRPM4 Drives Cerebral Edema by Switching to Alternative Splicing Isoform After Experimental Traumatic Brain Injury.
Title: TRPM4 Drives Cerebral Edema by Switching to Alternative Splicing Isoform After Experimental Traumatic Brain Injury.
Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice.
Title: Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice.
TRPM4 contribution in mouse uterine contractions.
Title: TRPM4 contribution in mouse uterine contractions.
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.
Title: Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

Trpm4 (e-PCR), detects polymorphism
- UniSTS:531249

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:235666

AW047689 (e-PCR)
- UniSTS:165523

NoName (e-PCR)
- UniSTS:235669

RH124609 (e-PCR)
- UniSTS:161431

Trpm4 (e-PCR), detects polymorphism
- UniSTS:530852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during Purkinje myocyte cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during Purkinje myocyte cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of atrial cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of sodium channel complex	IEA Inferred from Electronic Annotation more info
part_of sodium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 4

Names: calcium-activated non-selective cation channel 1; long transient receptor potential channel 4; transient receptor potential ion channel melastatin subgroup member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001435466.1 → NP_001422395.1 transient receptor potential cation channel subfamily M member 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC150897
NM_001435467.1 → NP_001422396.1 transient receptor potential cation channel subfamily M member 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC150897
NM_001435468.1 → NP_001422397.1 transient receptor potential cation channel subfamily M member 4 isoform 4

Status: VALIDATED

Source sequence(s)

AC150897
NM_175130.5 → NP_780339.2 transient receptor potential cation channel subfamily M member 4 isoform 1

See identical proteins and their annotated locations for NP_780339.2

Status: VALIDATED

Source sequence(s)

AC150897

Consensus CDS

CCDS52245.1

UniProtKB/Swiss-Prot

Q6PDM0, Q769E2, Q769E4, Q7TN37, Q80Y94, Q80YB3, Q811E2

Related

ENSMUSP00000040367.9, ENSMUST00000042194.10

Conserved Domains (1) summary

pfam00520
Location:855 → 943

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

44952579..44983495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153400.1 → XP_036009293.1 transient receptor potential cation channel subfamily M member 4 isoform X1
XM_006541146.5 → XP_006541209.1 transient receptor potential cation channel subfamily M member 4 isoform X2

UniProtKB/TrEMBL

A0A1B0GS49

Related

ENSMUSP00000147793.2, ENSMUST00000211743.2

Conserved Domains (2) summary

pfam00520
Location:708 → 796

Ion_trans; Ion transport protein

cl39032
Location:4 → 199

LSDAT_euk; SLOG in TRPM
XM_030242952.2 → XP_030098812.1 transient receptor potential cation channel subfamily M member 4 isoform X3

Conserved Domains (1) summary

pfam00520
Location:500 → 588

Ion_trans; Ion transport protein