Ncln nicalin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nclnprovided by MGI
Official Full Name: nicalinprovided by MGI
Primary source: MGI:MGI:1926081
See related: Ensembl:ENSMUSG00000020238 AllianceGenome:MGI:1926081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3100002P13Rik
Summary: Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 185.0), duodenum adult (RPKM 173.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81322289..81333178, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81486455..81496954, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in multi-pass transmembrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in multi-pass transmembrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of multi-pass translocon complex	ISO Inferred from Sequence Orthology more info
part_of multi-pass translocon complex	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BOS complex subunit NCLN

Names: nicalin homolog; nicastrin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134009.3 → NP_598770.1 BOS complex subunit NCLN precursor

See identical proteins and their annotated locations for NP_598770.1

Status: PROVISIONAL

Source sequence(s)

BC019501

Consensus CDS

CCDS36000.1

UniProtKB/Swiss-Prot

Q8C7Y4, Q8VCM8, Q9CX81

Related

ENSMUSP00000020463.8, ENSMUST00000020463.14

Conserved Domains (1) summary

cd03882
Location:130 → 429

M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81322289..81333178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313762.3 → XP_017169251.1 BOS complex subunit NCLN isoform X1

UniProtKB/TrEMBL

D3YU17

Related

ENSMUSP00000112744.2, ENSMUST00000118498.8

Conserved Domains (1) summary

cd03882
Location:127 → 429

M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein