Arg2 arginase type II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arg2provided by MGI
Official Full Name: arginase type IIprovided by MGI
Primary source: MGI:MGI:1330806
See related: Ensembl:ENSMUSG00000021125 AllianceGenome:MGI:1330806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AII
Summary: Predicted to enable arginase activity; manganese ion binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and negative regulation of cytokine production. Acts upstream of or within striated muscle contraction. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 66.9), small intestine adult (RPKM 62.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (79177562..79203075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (79130788..79156301)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism.
Title: Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism.
Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.
Title: Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.
Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice.
Title: Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice.
Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II.
Title: Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II.
Role of Arginase-II in Podocyte Injury under Hypoxic Conditions.
Title: Role of Arginase-II in Podocyte Injury under Hypoxic Conditions.
Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction.
Title: Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction.
Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis.
Title: Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis.
Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress.
Title: Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress.
Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice.
Title: Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice.
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Title: Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC86672P1 (e-PCR)
- UniSTS:273542

Arg2 (e-PCR), detects polymorphism
- UniSTS:527252

AU015348 (e-PCR)
- UniSTS:208826

AU022422 (e-PCR)
- UniSTS:180412

RH141711 (e-PCR)
- UniSTS:223704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to ornithine	ISO Inferred from Sequence Orthology more info
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arginine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine (C-C motif) ligand 4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage inflammatory protein 1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in regulation of L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: arginase-2, mitochondrial

Names: arginase II; kidney-type arginase; non-hepatic arginase; type II arginase

NP_033835.1

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.