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    Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 [ Mus musculus (house mouse) ]

    Gene ID: 66108, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ndufa9provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A9provided by MGI
    Primary source
    MGI:MGI:1913358
    See related
    Ensembl:ENSMUSG00000000399 AllianceGenome:MGI:1913358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1010001N11Rik
    Summary
    Predicted to enable NADH dehydrogenase activity. Predicted to be involved in circadian rhythm; mitochondrial respiratory chain complex I assembly; and ubiquinone biosynthetic process. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 197.9), kidney adult (RPKM 121.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufa9 in Genome Data Viewer
    Location:
    6 F3; 6 61.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126798826..126826107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126821863..126849144, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20190 Neighboring gene STARR-seq mESC enhancer starr_17397 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene Neighboring gene RIKEN cDNA 1700018A23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:126799059-126799305 Neighboring gene A kinase anchor protein 3 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice. Liu Y, et al. Int J Biochem Cell Biol, 2024 Jun. PMID 38657899
    2. Differential requirements for mitochondrial electron transport chain components in the adult murine liver. Lesner NP, et al. Elife, 2022 Sep 26. PMID 36154948, Free PMC Article
    3. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Ahn BH, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18794531, Free PMC Article
    4. Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease. Brosel S, et al. Am J Pathol, 2010 Nov. PMID 20864674, Free PMC Article
    5. Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus. Delavallée L, et al. Mol Metab, 2020 Oct. PMID 32480041, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice.
      Title: NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
    Names
    CI-39kD
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9
    NADH-ubiquinone oxidoreductase 39 kDa subunit
    complex I-39kD
    NP_079634.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025358.3 → NP_079634.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079634.2

      Status: VALIDATED

      Source sequence(s)
      AC165085, AK012366
      Consensus CDS
      CCDS20557.1
      UniProtKB/Swiss-Prot
      Q6GTD3, Q99JP9, Q9DC69
      UniProtKB/TrEMBL
      A0A0R3P9C8
      Related
      ENSMUSP00000144904.2, ENSMUST00000205002.3
      Conserved Domains (1) summary
      cd05271
      Location:54 → 326
      NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126798826..126826107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC69.2 GenPept UniProtKB/Swiss-Prot:Q9DC69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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