Spin1 spindlin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spin1provided by MGI
Official Full Name: spindlin 1provided by MGI
Primary source: MGI:MGI:109242
See related: Ensembl:ENSMUSG00000021395 AllianceGenome:MGI:109242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spin; SSEC P
Summary: Enables histone reader activity and methylated histone binding activity. Involved in protein localization to chromatin and transposable element silencing by piRNA-mediated DNA methylation. Located in spindle. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 12.2), whole brain E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 26.04 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (51254523..51306588)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (51097934..51152562)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two-factor authentication underpins the precision of the piRNA pathway.
Title: Two-factor authentication underpins the precision of the piRNA pathway.
Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma.
Title: Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma.
Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
Title: A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption.
Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of ribosomal RNA genes.
Title: Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.
Spin1 isoform2 is a protein expressed highly in adult testis, which might be involved in spermatogenesis and could be necessary for normal sperm motility
Title: Characterization of Spindlin1 isoform2 in mouse testis.
SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis
Title: Overexpression of SPINDLIN1 induces cellular senescence, multinucleation and apoptosis.
spindlin1 gene may contribute to tumorigenesis
Title: Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U48972 (e-PCR)
- UniSTS:125759

Spin (e-PCR), detects polymorphism
- UniSTS:144500

RH124326 (e-PCR)
- UniSTS:161148

RH124340 (e-PCR)
- UniSTS:161162

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiotic nuclear division	IC Inferred by Curator more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in rRNA transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spindlin-1

Names: 30000 Mr metaphase complex; spindlin1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001283028.2 → NP_001269957.1 spindlin-1 isoform 2

See identical proteins and their annotated locations for NP_001269957.1

Status: VALIDATED

Source sequence(s)

AC160122

Consensus CDS

CCDS26510.1

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91

Conserved Domains (1) summary

pfam02513
Location:54 → 102

Spin-Ssty; Spin/Ssty Family
NM_001283029.2 → NP_001269958.1 spindlin-1 isoform 2

See identical proteins and their annotated locations for NP_001269958.1

Status: VALIDATED

Source sequence(s)

AC160122

Consensus CDS

CCDS26510.1

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91

Conserved Domains (1) summary

pfam02513
Location:54 → 102

Spin-Ssty; Spin/Ssty Family
NM_001283030.2 → NP_001269959.1 spindlin-1 isoform 3

See identical proteins and their annotated locations for NP_001269959.1

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/TrEMBL

Q3UX91

Conserved Domains (1) summary

pfam02513
Location:29 → 77

Spin-Ssty; Spin/Ssty Family
NM_001419135.1 → NP_001406064.1 spindlin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91
NM_001419139.1 → NP_001406068.1 spindlin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91
NM_001419140.1 → NP_001406069.1 spindlin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91
NM_001419141.1 → NP_001406070.1 spindlin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91
NM_011462.4 → NP_035592.1 spindlin-1 isoform 1

See identical proteins and their annotated locations for NP_035592.1

Status: VALIDATED

Source sequence(s)

AC160122

UniProtKB/TrEMBL

Q3TQU6

Related

ENSMUST00000223152.2

Conserved Domains (1) summary

pfam02513
Location:32 → 80

Spin-Ssty; Spin/Ssty Family
NM_146043.5 → NP_666155.1 spindlin-1 isoform 2

See identical proteins and their annotated locations for NP_666155.1

Status: VALIDATED

Source sequence(s)

AC160122

Consensus CDS

CCDS26510.1

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91

Related

ENSMUSP00000093473.6, ENSMUST00000095797.6

Conserved Domains (1) summary

pfam02513
Location:54 → 102

Spin-Ssty; Spin/Ssty Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

51254523..51306588

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315469.3 → XP_017170958.1 spindlin-1 isoform X1

UniProtKB/Swiss-Prot

Q3TLC3, Q3UT05, Q61142, Q91VG8

UniProtKB/TrEMBL

Q3UX91

Conserved Domains (1) summary

pfam02513
Location:54 → 102

Spin-Ssty; Spin/Ssty Family