gnrh3 gonadotropin-releasing hormone 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnrh3provided by ZNC
Official Full Name: gonadotropin-releasing hormone 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030724-4
See related: Ensembl:ENSDARG00000056214 AllianceGenome:ZFIN:ZDB-GENE-030724-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sGnRH
Summary: Predicted to enable gonadotropin hormone-releasing hormone activity and gonadotropin-releasing hormone receptor binding activity. Involved in sex differentiation. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; gonad; male organism; nervous system; and olfactory region. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (20204122..20207291)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (20184286..20187455)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gnrh3 mutagenesis in zebrafish (Danio rerio) reveals no effects on reproductive performance
Title: Targeted Mutagenesis of the Hypophysiotropic Gnrh3 in Zebrafish (Danio rerio) Reveals No Effects on Reproductive Performance.
not indispensable for reproduction: while pulsatile release of GnRH to the portal system is the final gateway to stimulate the reproductive axis in mammals, multiple factors act in parallel with GnRH to stimulate the reproductive axis in certain fish species
Title: Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish.
close anatomical and functional relationship between Hcrt and GnRH3 neuronal systems in hypothalamus
Title: Morphological and Physiological Interactions Between GnRH3 and Hypocretin/Orexin Neuronal Systems in Zebrafish (Danio rerio).
Hedgehog-PKA pathway participates in the development of gnrh3-expressing neurons during embryogenesis
Title: Hedgehog-PKA signaling and gnrh3 regulate the development of zebrafish gnrh3 neurons.
IGF signaling affects the spatial distribution of newborn GnRH3 neurons by influencing neural crest cell migration and/or differentiation.
Title: Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish.
The presence of GnRH3 neurons of olfactory region origin in reproductively mature zebrafish is a prerequisite for normal oocyte development and reproduction.
Title: Targeted gonadotropin-releasing hormone-3 neuron ablation in zebrafish: effects on neurogenesis, neuronal migration, and reproduction.
These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish.
Title: Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish.
GnRH3 is an important factor regulating GnRH3 fibre pathfinding and neurone localisation in an autocrine fashion.
Title: Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor.
GnRH loss-of-function affects early brain and eye formation during development.
Title: A role for GnRH in early brain regionalization and eye development in zebrafish.
in situ hybridization analysis of expression in adult zebrafish brains; levels quantified in the pituitary
Title: Molecular characterization of the GnRH system in zebrafish (Danio rerio): cloning of chicken GnRH-II, adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRH-II.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gonadotropin hormone-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gonadotropin-releasing hormone 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.