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    spi1b Spi-1 proto-oncogene b [ Danio rerio (zebrafish) ]

    Gene ID: 30117, updated on 15-Dec-2024

    Summary

    Official Symbol
    spi1bprovided by ZNC
    Official Full Name
    Spi-1 proto-oncogene bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-164
    See related
    Ensembl:ENSDARG00000000767 AllianceGenome:ZFIN:ZDB-GENE-980526-164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pu1; pu.1; spi1; sfpi1; cb1086; si:by184l24.2
    Summary
    Enables sequence-specific DNA binding activity. Involved in macrophage activation involved in immune response and macrophage differentiation. Acts upstream of or within myeloid cell differentiation; negative regulation of myeloid cell differentiation; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; trunk; and yolk. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See spi1b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (32644673..32659345, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (32373523..32388235, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch73-314g15.3 Neighboring gene ADP-ribosylation factor-like 14 effector protein Neighboring gene uncharacterized LOC137496177 Neighboring gene solute carrier family 39 member 13 Neighboring gene transmembrane protein 276b Neighboring gene growth arrest-specific 2b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte development PubMed 
    involved_in macrophage activation involved in immune response PubMed 
    acts_upstream_of_or_within macrophage differentiation PubMed 
    involved_in macrophage differentiation PubMed 
    involved_in macrophage differentiation PubMed 
    acts_upstream_of_or_within myeloid cell differentiation PubMed 
    acts_upstream_of_or_within myeloid cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of erythrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of neutrophil differentiation PubMed 
    acts_upstream_of_or_within negative regulation of neutrophil differentiation PubMed 
    acts_upstream_of_or_within neutrophil differentiation PubMed 
    acts_upstream_of_or_within osteoclast development PubMed 
    acts_upstream_of_or_within osteoclast development PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    transcription factor PU.1b
    Names
    spleen focus forming virus (SFFV) proviral integration oncogene spi1
    spleen focus forming virus (SFFV) proviral integration oncogene spi1b
    transcription factor spi1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328368.1 → NP_001315297.1  transcription factor PU.1b isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929252, CT030129
      UniProtKB/TrEMBL
      A0A8M1PA68, F1R668
      Related
      ENSDARP00000087711.3, ENSDART00000093279.5
      Conserved Domains (1) summary
      smart00413
      Location:167 → 255
      ETS; erythroblast transformation specific domain
    2. NM_001328369.1 → NP_001315298.1  transcription factor PU.1b isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929252, CT030129
      UniProtKB/TrEMBL
      A0A8M1P911, Q8AW41
      Related
      ENSDARP00000109500.2, ENSDART00000126831.2
      Conserved Domains (1) summary
      smart00413
      Location:166 → 254
      ETS; erythroblast transformation specific domain
    3. NM_198062.2 → NP_932328.2  transcription factor PU.1b isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL929252, CT030129
      UniProtKB/TrEMBL
      A0A8M1PEY8, F1RBC1, Q78AM8
      Related
      ENSDARP00000029369.5, ENSDART00000036729.7
      Conserved Domains (1) summary
      smart00413
      Location:197 → 285
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      32644673..32659345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168848.5 → XP_005168905.1  transcription factor PU.1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BG46
      Conserved Domains (1) summary
      smart00413
      Location:198 → 286
      ETS; erythroblast transformation specific domain
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