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    chst11 carbohydrate (chondroitin 4) sulfotransferase 11 [ Danio rerio (zebrafish) ]

    Gene ID: 404232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chst11provided by ZNC
    Official Full Name
    carbohydrate (chondroitin 4) sulfotransferase 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040315-1
    See related
    Ensembl:ENSDARG00000034375 AllianceGenome:ZFIN:ZDB-GENE-040315-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    C4ST1
    Summary
    Enables chondroitin 4-sulfotransferase activity. Acts upstream of or within chondroitin sulfate biosynthetic process; motor neuron axon guidance; and muscle organ development. Predicted to be located in Golgi membrane. Is expressed in several structures, including central nervous system; notochord; pectoral fin bud; spinal cord neural keel; and spinal cord neural tube. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chst11 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (9103185..9173562, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (9101852..9172886, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene NOP protein chaperone 1 Neighboring gene solute carrier family 41 member 2b Neighboring gene nuclear transcription factor Y, beta a Neighboring gene host cell factor C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury. Sahu S, et al. FASEB J, 2019 Feb. PMID 30339470
    2. Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish. Mizumoto S, et al. Biochem J, 2009 Apr 15. PMID 19125692
    3. TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development. Flanagan-Steet H, et al. Cell Rep, 2018 Mar 13. PMID 29539424, Free PMC Article
    4. Chondroitin / dermatan sulfate modification enzymes in zebrafish development. Habicher J, et al. PLoS One, 2015. PMID 25793894, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152824

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chondroitin 4-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chondroitin 4-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 11
    Names
    C4ST-1
    chondroitin 4-O-sulfotransferase 1
    chondroitin 4-sulfotransferase 1
    zC4ST-1
    NP_997989.2
    XP_005168579.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212824.2 → NP_997989.2  carbohydrate sulfotransferase 11

      See identical proteins and their annotated locations for NP_997989.2

      Status: PROVISIONAL

      Source sequence(s)
      BC124140
      UniProtKB/Swiss-Prot
      Q7T3S3
      UniProtKB/TrEMBL
      Q08CQ4
      Related
      ENSDARP00000042962.4, ENSDART00000042963.6
      Conserved Domains (1) summary
      pfam03567
      Location:113 → 343
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      9103185..9173562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168522.5 → XP_005168579.1  carbohydrate sulfotransferase 11 isoform X1

      UniProtKB/Swiss-Prot
      Q7T3S3
      UniProtKB/TrEMBL
      A0A8M2BGG9
      Conserved Domains (1) summary
      pfam03567
      Location:108 → 338
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3S3.1 GenPept UniProtKB/Swiss-Prot:Q7T3S3

    Gene LinkOut

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