ptpa protein phosphatase 2 phosphatase activator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpaprovided by ZNC
Official Full Name: protein phosphatase 2 phosphatase activatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-11
See related: Ensembl:ENSDARG00000031985 AllianceGenome:ZFIN:ZDB-GENE-040801-11
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ppp2r4; fc23d07; zgc:92766; wu:fc23d07
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32797890..32813992, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (32197737..32213839, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A activator

Names: protein phosphatase 2A activator, regulatory subunit 4

NP_001003425.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003425.2 → NP_001003425.2 serine/threonine-protein phosphatase 2A activator

Status: VALIDATED

Source sequence(s)

CR925757, EH505535

UniProtKB/TrEMBL

A0A8M1N1B5, A2CF49

Related

ENSDARP00000118562.1, ENSDART00000135864.3

Conserved Domains (1) summary

pfam03095
Location:28 → 321

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein