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    sqstm1 sequestosome 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqstm1provided by ZNC
    Official Full Name
    sequestosome 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2204
    See related
    Ensembl:ENSDARG00000075014 AllianceGenome:ZFIN:ZDB-GENE-040426-2204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    p62; sb:cb621; zgc:85784
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Acts upstream of or within several processes, including axonogenesis; defense response to bacterium; and regulation of autophagy. Predicted to be located in cytoplasm and nucleus. Predicted to be active in aggresome and amphisome. Is expressed in several structures, including digestive system; epidermis; mesoderm; muscle; and nervous system. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sqstm1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16765992..16771405)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (16460339..16465752)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene calnexin Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b Neighboring gene MRN complex interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Zhang Y, et al. Cell Chem Biol, 2017 Apr 20. PMID 28366621
    2. Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD. Lattante S, et al. Hum Mol Genet, 2015 Mar 15. PMID 25410659
    3. Establishment of a zebrafish inbred strain, M-AB, capable of regular breeding and genetic manipulation. Sadamitsu K, et al. Sci Rep, 2024 Mar 29. PMID 38548817, Free PMC Article
    4. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Swinnen B, et al. Acta Neuropathol, 2018 Mar. PMID 29302778
    5. Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. Muto V, et al. Neurology, 2018 Jul 24. PMID 29959261, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in amphisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sequestosome-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312913.1 → NP_001299842.1  sequestosome-1

      Status: VALIDATED

      Source sequence(s)
      CU075768, DR724012, EH505876, EH510853
      UniProtKB/TrEMBL
      A0A096X7A4, F1Q5Z8
      Related
      ENSDARP00000117113.1, ENSDART00000140061.3
      Conserved Domains (3) summary
      cd06402
      Location:3 → 88
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:148 → 190
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl21463
      Location:390 → 448
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      16765992..16771405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213173.1: Suppressed sequence

      Description
      NM_213173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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