terf2ip telomeric repeat binding factor 2, interacting protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: terf2ipprovided by ZNC
Official Full Name: telomeric repeat binding factor 2, interacting proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-131121-641
See related: Ensembl:ENSDARG00000103977 AllianceGenome:ZFIN:ZDB-GENE-131121-641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RAP1
Summary: Predicted to enable telomeric DNA binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; regulation of nucleobase-containing compound metabolic process; and telomere maintenance. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (34598805..34614169, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (34623898..34639299, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging
Title: The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA recombination at telomere	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protection from non-homologous end joining at telomere	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in protection from non-homologous end joining at telomere	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomere lengthening	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomeric repeat-binding factor 2-interacting protein 1

Names: RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; zmp:0000000584

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202416.1 → NP_001189345.1 telomeric repeat-binding factor 2-interacting protein 1

See identical proteins and their annotated locations for NP_001189345.1

Status: VALIDATED

Source sequence(s)

CABZ01048351, CU481774

UniProtKB/Swiss-Prot

Q5BKV6, Q6NYJ3

UniProtKB/TrEMBL

A0A0R4IRZ2, A0A8M1P1Q7

Related

ENSDARP00000131029.1, ENSDART00000158690.2

Conserved Domains (3) summary

cd11653
Location:519 → 613

rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

pfam08914
Location:116 → 177

Myb_DNA-bind_2; Rap1 Myb domain

pfam16589
Location:11 → 97

BRCT_2; BRCT domain, a BRCA1 C-terminus domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

34598805..34614169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216276.1 → XP_068072377.1 telomeric repeat-binding factor 2-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5BKV6, Q6NYJ3

UniProtKB/TrEMBL

A0A8M3B5S4
XM_009296495.3 → XP_009294770.1 telomeric repeat-binding factor 2-interacting protein 1 isoform X2

See identical proteins and their annotated locations for XP_009294770.1

UniProtKB/Swiss-Prot

Q5BKV6, Q6NYJ3

UniProtKB/TrEMBL

A0A0R4IRZ2, A0A8M1P1Q7

Related

ENSDARP00000139292.1, ENSDART00000171712.2

Conserved Domains (3) summary

cd11653
Location:519 → 613

rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

pfam08914
Location:116 → 177

Myb_DNA-bind_2; Rap1 Myb domain

pfam16589
Location:11 → 97

BRCT_2; BRCT domain, a BRCA1 C-terminus domain
XM_009296493.4 → XP_009294768.2 telomeric repeat-binding factor 2-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5BKV6, Q6NYJ3

UniProtKB/TrEMBL

A0A8M3B5S4