cldnj claudin j [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cldnjprovided by ZNC
Official Full Name: claudin jprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010328-10
See related: Ensembl:ENSDARG00000058880 AllianceGenome:ZFIN:ZDB-GENE-010328-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cldn8l; fc30g01; wu:fc30g01
Summary: Predicted to enable structural molecule activity. Acts upstream of or within lifelong otolith mineralization. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in central nervous system; otic epithelium; otic vesicle; and ovary. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 116. Orthologous to human CLDN6 (claudin 6) and CLDN9 (claudin 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (2631211..2632891, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (2666745..2669319, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of cldnh during the early retinal development in zebrafish.
Title: The role of cldnh during the early retinal development in zebrafish.
Morpholino inhibition of claudinj expression showed similar defects in otolith formation.
Title: The zebrafish gene claudinj is essential for normal ear function and important for the formation of the otoliths.

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General gene information

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Markers

AI722717 (e-PCR)
- UniSTS:205987

fc30g01.x1 (e-PCR)
- UniSTS:193492

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lifelong otolith mineralization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: claudin j

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131769.2 → NP_571844.2 claudin j

Status: VALIDATED

Source sequence(s)

CR382327

UniProtKB/TrEMBL

A0A8N7UZN0, Q90XR4

Related

ENSDARP00000076279.1, ENSDART00000081840.3

Conserved Domains (1) summary

cl21598
Location:1 → 178

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family