lpp LIM domain containing preferred translocation partner in lipoma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lppprovided by ZNC
Official Full Name: LIM domain containing preferred translocation partner in lipomaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-918
See related: Ensembl:ENSDARG00000023578 AllianceGenome:ZFIN:ZDB-GENE-040426-918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc26e09; zgc:56152; wu:fc26e09
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within dorsal convergence. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including axis; cardiovascular system; digestive system; tail bud; and unfertilized egg. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (28294199..28690670)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (28303638..28695854)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lpp interacts with the PCP protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.
Title: Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

G40035 (e-PCR)
- UniSTS:72462

fc26e09.x1 (e-PCR)
- UniSTS:193311

fc26e09.x1 (e-PCR)
- UniSTS:193312

G46079 (e-PCR)
- UniSTS:106881

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lipoma-preferred partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201198.1 → NP_957492.1 lipoma-preferred partner

See identical proteins and their annotated locations for NP_957492.1

Status: PROVISIONAL

Source sequence(s)

BC050503

UniProtKB/TrEMBL

Q7ZU85

Related

ENSDARP00000113831.2, ENSDART00000136898.3

Conserved Domains (4) summary

cd09350
Location:360 → 413

LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

cd09436
Location:480 → 545

LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

pfam10310
Location:123 → 201

DUF2413; Protein of unknown function (DUF2413)

cl02475
Location:420 → 479

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers