dbx2 developing brain homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dbx2provided by ZNC
Official Full Name: developing brain homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000128-13
See related: Ensembl:ENSDARG00000105053 AllianceGenome:ZFIN:ZDB-GENE-000128-13
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hlx3; zgc:110519
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within swimming behavior. Predicted to be located in nucleus. Is expressed in eye; spinal cord; spinal cord neural tube; and tegmentum. Orthologous to human DBX2 (developing brain homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: Un

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_008805503.1 (3202..6421, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_008805503.1 (4178..7053, complement)

NW_008805503.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

hlx3 (e-PCR)
- UniSTS:205612

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: developing brain homeobox 2; homeobox protein DBX2

Names: H2.0-like homeobox 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NW_008805503.1 Reference GRCz11 Primary Assembly

Range

3202..6421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470994.2 → XP_021326669.1 homeobox protein DBX2

UniProtKB/TrEMBL

A0A8M9PP76

Related

ENSDARP00000132527.1, ENSDART00000159746.2

Conserved Domains (1) summary

pfam00046
Location:102 → 155

Homeobox; Homeobox domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_131179.1: Suppressed sequence

Description

NM_131179.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DBX2 (GeneID:440097).