kdrl kinase insert domain receptor like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kdrlprovided by ZNC
Official Full Name: kinase insert domain receptor likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000705-1
See related: Ensembl:ENSDARG00000105215 AllianceGenome:ZFIN:ZDB-GENE-000705-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: flk; kdr; flk1; kdra; flk-1; vegr2; vegfr2; vegfr4; vegfr-2; vegfr2a; wu:fk52c05
Summary: Enables protein tyrosine kinase activity. Involved in angiogenesis and peptidyl-tyrosine phosphorylation. Acts upstream of or within circulatory system development and thyroid gland development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; head; hematopoietic system; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The name of this locus was changed from kdr to kdrl to conform to the name reported by the Zebrafish Information Network. [28 Jul 2008]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (32985253..33044555, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (32643455..32704627, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.
Title: The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.
Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis.
Title: Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis.
Study shows that zebrafish sec14l3, one of the Sec14-like phosphatidylinositol transfer proteins family members, specifically participates in artery and vein formation via regulating angioblasts and subsequent venous progenitors' migration during vasculogenesis via the regulation of VEGFR2 activation.
Title: Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis.
Ca(2+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal vein, respectively.
Title: Endothelial Ca 2+ oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo.
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
Title: High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade.
methylation of Lys(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.
Title: Lysine methylation promotes VEGFR-2 activation and angiogenesis.
Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Title: A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10]
Title: MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.
Early Flk1 expression may be induced by cooperative interactions between Gata, Tcf/Lef, Cdx and ER71/Etv2 under the control of Bmp, Wnt and Fgf signaling.
Title: Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b and VEGFR2 act additively to control angiogenesis in vivo.
Title: Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

FLK1 (e-PCR)
- UniSTS:205382

fj51g12.y1 (e-PCR)
- UniSTS:199505

Z7803 (e-PCR)
- UniSTS:204659

fk52c05.x1 (e-PCR)
- UniSTS:201122

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vascular endothelial growth factor receptor kdr-like

Names: VEGFR-4; fetal liver kinase 1; flt1b; kinase insert domain receptor-A; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 4; vascular endothelial growth factor receptor type 2

NP_571547.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131472.1 → NP_571547.1 vascular endothelial growth factor receptor kdr-like precursor

See identical proteins and their annotated locations for NP_571547.1

Status: PROVISIONAL

Source sequence(s)

AY056466

UniProtKB/TrEMBL

A0A8M3AGQ5

Related

ENSDARP00000134625.1, ENSDART00000170626.2

Conserved Domains (6) summary

cd00096
Location:659 → 725

Ig; Immunoglobulin domain

smart00410
Location:228 → 319

IG_like; Immunoglobulin like

pfam07679
Location:646 → 728

I-set; Immunoglobulin I-set domain

pfam07714
Location:808 → 1134

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:343 → 415

Ig; Immunoglobulin domain

cl21453
Location:800 → 1141

PKc_like; Protein Kinases, catalytic domain