U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    syne1b spectrin repeat containing, nuclear envelope 1b [ Danio rerio (zebrafish) ]

    Gene ID: 567576, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    syne1bprovided by ZNC
    Official Full Name
    spectrin repeat containing, nuclear envelope 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071218-4
    See related
    Ensembl:ENSDARG00000063068 AllianceGenome:ZFIN:ZDB-GENE-071218-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    syne1
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within heart development. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See syne1b in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    148
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (7844910..8148154, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (7687731..8016243, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene coiled-coil domain containing 170 Neighboring gene myc target 1b Neighboring gene TUB like protein 4b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Zhou C, et al. Hum Mol Genet, 2017 Jun 15. PMID 28398466, Free PMC Article
    2. Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. Haskell GT, et al. Circ Cardiovasc Genet, 2017 Jun. PMID 28611029, Free PMC Article
    3. Syne2b/Nesprin-2 Is Required for Actin Organization and Epithelial Integrity During Epiboly Movement in Zebrafish. Li YL, et al. Front Cell Dev Biol, 2021. PMID 34222245, Free PMC Article
    4. Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Tsujikawa M, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17785424, Free PMC Article
    5. Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Shih YH, et al. Circ Cardiovasc Genet, 2015 Apr. PMID 25583992, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nesprin-1
    Names
    spectrin repeat containing, nuclear envelope 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      7844910..8148154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214521.1 → XP_068070622.1  nesprin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AIP9
      Related
      ENSDARP00000124184.1, ENSDART00000148520.3

    2. XM_068214520.1 → XP_068070621.1  nesprin-1 isoform X4

    3. XM_009292834.4 → XP_009291109.2  nesprin-1 isoform X2

    4. XM_068214519.1 → XP_068070620.1  nesprin-1 isoform X3

    5. XM_017351755.3 → XP_017207244.2  nesprin-1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials