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    mtch2 mitochondrial carrier homolog 2 [ Danio rerio (zebrafish) ]

    Gene ID: 30655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtch2provided by ZNC
    Official Full Name
    mitochondrial carrier homolog 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991008-9
    See related
    Ensembl:ENSDARG00000019732 AllianceGenome:ZFIN:ZDB-GENE-991008-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi20c06; fj35g12; wu:fi20c06; wu:fj35g12
    Summary
    Involved in adipose tissue development. Acts upstream of or within digestive tract development; fat cell differentiation; and liver development. Predicted to be located in mitochondrial outer membrane. Predicted to be active in membrane and mitochondrion. Is expressed in several structures, including central nervous system; head; liver; male organism; and pleuroperitoneal region. Orthologous to human MTCH2 (mitochondrial carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtch2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38667111..38678090)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38395856..38406831)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene nephrosin Neighboring gene six-cysteine containing astacin protease 1 Neighboring gene proteasome 26S subunit, ATPase 3 Neighboring gene uncharacterized LOC137496187 Neighboring gene apelin receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. Landgraf K, et al. FEBS Lett, 2016 Sep. PMID 27468124
    2. Evolution of teleostean hatching enzyme genes and their paralogous genes. Kawaguchi M, et al. Dev Genes Evol, 2006 Dec. PMID 17016731
    3. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
    4. Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Zhang J, et al. Front Endocrinol (Lausanne), 2018. PMID 30631305, Free PMC Article
    5. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings indicate an essential role for mtch2 during organ development and adipogenesis in vivo.
      Title: Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial carrier homolog 2
    Names
    etID15240.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131382.1 → NP_571457.1  mitochondrial carrier homolog 2

      See identical proteins and their annotated locations for NP_571457.1

      Status: PROVISIONAL

      Source sequence(s)
      AF176010
      UniProtKB/TrEMBL
      F6P3G0, Q789I7, Q9PUL9
      Related
      ENSDARP00000016602.5, ENSDART00000013394.6
      Conserved Domains (1) summary
      pfam00153
      Location:125 → 189
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      38667111..38678090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477393.2 → XP_021333068.1  mitochondrial carrier homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q165
      Conserved Domains (1) summary
      pfam00153
      Location:124 → 188
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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