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    stk24b serine/threonine kinase 24b (STE20 homolog, yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 406786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stk24bprovided by ZNC
    Official Full Name
    serine/threonine kinase 24b (STE20 homolog, yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2841
    See related
    Ensembl:ENSDARG00000023878 AllianceGenome:ZFIN:ZDB-GENE-040426-2841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    stk24; zgc:66137; wu:fi29b08
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within heart development. Predicted to be active in Golgi apparatus. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stk24b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (12482599..12551474)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12247741..12316607)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate dehydrogenase 2 (mitochondrial) Neighboring gene uncharacterized LOC103911182 Neighboring gene nuclear receptor subfamily 4, group A, member 2b Neighboring gene solute carrier family 15 member 1b Neighboring gene uncharacterized LOC137495931 Neighboring gene dedicator of cytokinesis 9b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. Zheng X, et al. J Clin Invest, 2010 Aug. PMID 20592472, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
      Title: CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 24
    Names
    serine/threonine kinase 24 (STE20 homolog, yeast)
    NP_998642.1
    XP_005165890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213477.1 → NP_998642.1  serine/threonine-protein kinase 24

      See identical proteins and their annotated locations for NP_998642.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054651
      UniProtKB/TrEMBL
      Q7SYN3
      Related
      ENSDARP00000084749.4, ENSDART00000090316.6
      Conserved Domains (2) summary
      smart00220
      Location:12 → 262
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:10 → 283
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      12482599..12551474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165833.5 → XP_005165890.1  serine/threonine-protein kinase 24 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IN78, A0A8M2BD45
      Related
      ENSDARP00000135203.1, ENSDART00000171460.2
      Conserved Domains (2) summary
      smart00220
      Location:24 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:22 → 295
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.