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    pja2 praja ring finger ubiquitin ligase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 565118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pja2provided by ZNC
    Official Full Name
    praja ring finger ubiquitin ligase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-337
    See related
    Ensembl:ENSDARG00000100296 AllianceGenome:ZFIN:ZDB-GENE-060526-337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-79c1.2
    Summary
    Predicted to enable metal ion binding activity. Is expressed in brain; head mesenchyme; post-vent vasculature; trunk vasculature; and yolk syncytial layer. Orthologous to several human genes including PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pja2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (57210237..57234124)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (56539988..56563907)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2A, member 1 Neighboring gene uncharacterized LOC103911128 Neighboring gene uncharacterized LOC101886669 Neighboring gene fer (fps/fes related) tyrosine kinase Neighboring gene uncharacterized LOC137495640 Neighboring gene ATPase H+ transporting V1 subunit G1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Shin J, et al. Genes Cancer, 2017 Jul. PMID 28966725, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Praja-2
    Names
    praja ring finger 2
    NP_001098586.2
    XP_009300150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105116.2 → NP_001098586.2  E3 ubiquitin-protein ligase Praja-2

      Status: VALIDATED

      Source sequence(s)
      CT009691, FP928982
      UniProtKB/TrEMBL
      A0A0R4IPD9, A0A8M1NFW1
      Related
      ENSDARP00000138079.1, ENSDART00000167660.2
      Conserved Domains (1) summary
      pfam13639
      Location:587 → 628
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      57210237..57234124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301875.3 → XP_009300150.1  E3 ubiquitin-protein ligase Praja-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AZZ7
      Conserved Domains (1) summary
      pfam13639
      Location:588 → 629
      zf-RING_2; Ring finger domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394616.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      17625..41506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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