U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ewsr1a EWS RNA-binding protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 323597, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ewsr1aprovided by ZNC
    Official Full Name
    EWS RNA-binding protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2317
    See related
    Ensembl:ENSDARG00000020258 AllianceGenome:ZFIN:ZDB-GENE-030131-2317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    EWSR1; fc04c01; wu:fc04c01
    Summary
    Enables chromatin binding activity. Acts upstream of or within several processes, including mitotic spindle midzone assembly; regulation of chondrocyte hypertrophy; and regulation of mitotic nuclear division. Predicted to be active in nucleus. Is expressed in fin bud; nervous system; and trunk. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ewsr1a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7975585..7988412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (8016885..8029728, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E4 Neighboring gene oxysterol binding protein 2a Neighboring gene ATPase H+ transporting V0 subunit a2a Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish. Park H, et al. Sci Rep, 2016 Aug 25. PMID 27557633, Free PMC Article
    2. Reversible and Irreversible Aggregation of Proteins from the FET Family: Influence of Repeats in Protein Chain on Its Aggregation Capacity. Galzitskaya OV. Curr Protein Pept Sci, 2016. PMID 26100283
    3. Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. Embree LJ, et al. Cancer Res, 2009 May 15. PMID 19417137, Free PMC Article
    4. Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. Azuma M, et al. PLoS One, 2007 Oct 3. PMID 17912356, Free PMC Article
    5. Characterization of genetic loss-of-function of Fus in zebrafish. Lebedeva S, et al. RNA Biol, 2017 Jan 2. PMID 27898262, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of the EWS gene modulates Sox9 gene expression essential for chondrocyte differentiation.
      Title: Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish.
    2. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
      Title: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
    3. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
      Title: Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of chondrocyte hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    EWS RNA-binding protein 1a
    Names
    Ewing sarcoma breakpoint region 1
    Ewing sarcoma breakpoint region 1a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115138.2 → NP_001108610.1  EWS RNA-binding protein 1a

      See identical proteins and their annotated locations for NP_001108610.1

      Status: VALIDATED

      Source sequence(s)
      BC068397, CN835703, DT075886, EH467947, FP131351, FP154885
      UniProtKB/TrEMBL
      A0A0B4J1A5, A0A8N1TRE3, Q6NUX1
      Related
      ENSDARP00000024102.7, ENSDART00000024282.9
      Conserved Domains (4) summary
      COG0724
      Location:329 → 431
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:346 → 429
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:499 → 520
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:495 → 525
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      7975585..7988412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479109.2 → XP_021334784.1  EWS RNA-binding protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBU8, Q6NUX1
      Conserved Domains (3) summary
      cd12533
      Location:317 → 400
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:470 → 491
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:466 → 496
      zf-RanBP; Zn-finger in Ran binding protein and others

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394766.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      140953..153780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools