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    cse1l CSE1 chromosome segregation 1-like (yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 30707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cse1lprovided by ZNC
    Official Full Name
    CSE1 chromosome segregation 1-like (yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990603-1
    See related
    Ensembl:ENSDARG00000006963 AllianceGenome:ZFIN:ZDB-GENE-990603-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cas
    Summary
    Predicted to enable nuclear export signal receptor activity. Acts upstream of or within body fluid secretion. Predicted to be located in several cellular components, including apical plasma membrane; basal plasma membrane; and lateral plasma membrane. Predicted to be active in cytosol and nuclear envelope. Is expressed in brain; digestive system; endoderm; and retina. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cse1l in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (5468772..5490184)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (5522466..5543878)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene bis(5'-adenosyl)-triphosphatase-like Neighboring gene protein tyrosine phosphatase receptor type Ga Neighboring gene uncharacterized LOC137496665 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene si:ch73-40i7.2 Neighboring gene solute carrier family 35 member E1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cse1l is a negative regulator of CFTR-dependent fluid secretion. Bagnat M, et al. Curr Biol, 2010 Oct 26. PMID 20933420, Free PMC Article
    2. Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Chiarelli N, et al. Int J Dev Biol, 2011. PMID 21553381
    3. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
    4. A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences. Gates MA, et al. Genome Res, 1999 Apr. PMID 10207156
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within body fluid secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exportin-2
    Names
    bao
    baobab
    cellular apoptosis susceptibilit
    cellular apoptosis susceptibility
    chromosome segregation 1-like protein
    exp2
    importin-alpha re-exporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201450.1 → NP_958858.1  exportin-2

      See identical proteins and their annotated locations for NP_958858.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052479
      UniProtKB/Swiss-Prot
      G1K2H9, Q7SZC2
      Related
      ENSDARP00000022858.7, ENSDART00000013203.9
      Conserved Domains (3) summary
      smart00913
      Location:29 → 102
      IBN_N; Importin-beta N-terminal domain
      pfam03378
      Location:527 → 962
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam08506
      Location:156 → 525
      Cse1; Cse1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      5468772..5490184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SZC2.2 GenPept UniProtKB/Swiss-Prot:Q7SZC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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