trrap transformation/transcription domain-associated protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trrapprovided by ZNC
Official Full Name: transformation/transcription domain-associated proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050809-47
See related: Ensembl:ENSDARG00000100623 AllianceGenome:ZFIN:ZDB-GENE-050809-47
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc54d09; im:7154030; wu:fc54d09
Summary: Predicted to enable protein kinase activity. Involved in neuromast hair cell development and startle response. Acts upstream of or within cartilage morphogenesis and regulation of odontogenesis. Predicted to be part of NuA4 histone acetyltransferase complex and SAGA complex. Predicted to be active in nucleus. Is expressed in head. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 72

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (17927871..18105116)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (17806001..17983225)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc54d09 (e-PCR)
- UniSTS:189338

ha2154 (e-PCR)
- UniSTS:515495

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transformation/transcription domain-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423950.1 → NP_001410879.1 transformation/transcription domain-associated protein isoform 1

Status: VALIDATED

Source sequence(s)

BX005075, BX571829, FO082787

UniProtKB/TrEMBL

A0A8M3B4M5
NM_001423951.1 → NP_001410880.1 transformation/transcription domain-associated protein isoform 2

Status: VALIDATED

Source sequence(s)

BX005075, BX571829, FO082787

UniProtKB/TrEMBL

A0A0R4IPE4, A0A8M9QMW1

Related

ENSDARP00000137500.1, ENSDART00000172062.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

17927871..18105116

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306682.4 → XP_009304957.1 transformation/transcription domain-associated protein isoform X1

UniProtKB/Swiss-Prot

A0A0R4ITC5

Related

ENSDARP00000137625.1, ENSDART00000160586.2

Conserved Domains (3) summary

cd05163
Location:3478 → 3765

PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

pfam02259
Location:2827 → 3169

FAT; FAT domain

pfam02260
Location:3814 → 3841

FATC; FATC domain