slc26a5 solute carrier family 26 member 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc26a5provided by ZNC
Official Full Name: solute carrier family 26 member 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1566
See related: Ensembl:ENSDARG00000022424 AllianceGenome:ZFIN:ZDB-GENE-030131-1566
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pres; fb73d12; fb74g12; wu:fb73d12; wu:fb74g12
Summary: Enables formate transmembrane transporter activity; oxalate:chloride antiporter activity; and sulfate:chloride antiporter activity. Acts upstream of or within several processes, including chloride transport; oxalate transport; and sulfate transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in hair cell; inner ear; lagena; utricle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (14932537..14954029, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (14933782..14955274, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results show, for the first time, that the substitution of a span of 11 amino acid residues confers the electrogenic anion transporters of zebrafish and chicken prestins with motor-like function
Title: A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.
Motor function is an innovation of therian prestin and is concurrent with diminished transporter capabilities.
Title: From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.
Compared with mammalian prestin, charge movements mediated by zprestin display a weaker voltage dependence and slower kinetics; they occur at more positive membrane voltages, and are not associated with electromotile responses.
Title: Voltage-sensitive prestin orthologue expressed in zebrafish hair cells.
sequence conservation between mammalian and nonmammalian prestin together with a common pharmacology of electromotility and divalent antiport
Title: Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers.

Submit: New GeneRIF Correction

General gene information

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Markers

fb73d12 (e-PCR)
- UniSTS:187439

fb73d12.x1 (e-PCR)
- UniSTS:191158

fb74g12.x1 (e-PCR)
- UniSTS:191215

fb74g12.x1 (e-PCR)
- UniSTS:191216

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables formate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxalate:chloride antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables secondary active sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate:chloride antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cochlear outer hair cell electromotile response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oxalate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prestin

Names: solute carrier family 26 (anion exchanger), member 5; zprestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201473.1 → NP_958881.1 prestin

See identical proteins and their annotated locations for NP_958881.1

Status: PROVISIONAL

Source sequence(s)

BC054604

UniProtKB/Swiss-Prot

A0A8M1PEF9, Q7T2C4

Related

ENSDARP00000036010.3, ENSDART00000038642.4

Conserved Domains (3) summary

cd07042
Location:643 → 719

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:67 → 722

sulP; high affinity sulphate transporter 1

cl00596
Location:259 → 366

LrgB; LrgB-like family