alas1 aminolevulinate, delta-, synthase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alas1provided by ZNC
Official Full Name: aminolevulinate, delta-, synthase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-001229-2
See related: Ensembl:ENSDARG00000021059 AllianceGenome:ZFIN:ZDB-GENE-001229-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ALAS-N; unm_sm350; wu:fb58d01; wu:fi12g09; wu:fq33a02
Summary: Predicted to enable 5-aminolevulinate synthase activity. Acts upstream of or within neutrophil differentiation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including EVL; digestive system; periderm; polster; and pronephros. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (260763..270210, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (241309..250756, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alas1-deficient zebrafish showed impaired bactericidal ability and augmented inflammatory responses when challenged with Escherichia coli These findings demonstrate the important role of Alas1 in regulating neutrophil maturation and physiological function through the heme.
Title: Alas1 is essential for neutrophil maturation in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G46754 (e-PCR)
- UniSTS:107551

fb58d01.x1 (e-PCR)
- UniSTS:190806

fi12g09.x1 (e-PCR)
- UniSTS:196805

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5-aminolevulinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-aminolevulinate synthase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hemoglobin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-aminolevulinate synthase, non-specific, mitochondrial

Names: aminolevulinate, delta-, synthetase 1

NP_958444.1

EC 2.3.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201287.1 → NP_958444.1 5-aminolevulinate synthase, non-specific, mitochondrial

See identical proteins and their annotated locations for NP_958444.1

Status: PROVISIONAL

Source sequence(s)

BC054574

UniProtKB/TrEMBL

Q7T2F0

Related

ENSDARP00000005771.8, ENSDART00000005217.9

Conserved Domains (3) summary

COG0156
Location:170 → 567

BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

pfam09029
Location:4 → 120

Preseq_ALAS; 5-aminolevulinate synthase presequence

cl18945
Location:170 → 575

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...