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    tgm1l4 transglutaminase 1 like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 555962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tgm1l4provided by ZNC
    Official Full Name
    transglutaminase 1 like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-29
    See related
    Ensembl:ENSDARG00000101407 AllianceGenome:ZFIN:ZDB-GENE-050913-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112355
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in keratinocyte differentiation. Predicted to act upstream of or within keratinization and peptide cross-linking. Predicted to be located in membrane. Is expressed in EVL and periderm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tgm1l4 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (46191869..46202138, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (46240643..46250912, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene bloodthirsty-related gene family, member 32 Neighboring gene uncharacterized LOC103909730 Neighboring gene bloodthirsty-related gene family, member 31 Neighboring gene zgc:162858

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the transglutaminase gene family in zebrafish and in vivo analysis of transglutaminase-dependent bone mineralization. Deasey S, et al. Amino Acids, 2012 Feb. PMID 21809079, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112355

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transglutaminase 1 like 4
    Names
    TG1-62
    NP_001025267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030096.1 → NP_001025267.1  transglutaminase 1 like 4

      See identical proteins and their annotated locations for NP_001025267.1

      Status: PROVISIONAL

      Source sequence(s)
      BC096890
      UniProtKB/TrEMBL
      A0A8M9PWI0, Q4V9H9
      Related
      ENSDARP00000136459.1, ENSDART00000160110.3
      Conserved Domains (3) summary
      smart00460
      Location:308 → 399
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:47 → 161
      Transglut_N; Transglutaminase family
      pfam00927
      Location:629 → 726
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      46191869..46202138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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