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    plaa phospholipase A2-activating protein [ Danio rerio (zebrafish) ]

    Gene ID: 324855, updated on 4-Jan-2025

    Summary

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    Official Symbol
    plaaprovided by ZNC
    Official Full Name
    phospholipase A2-activating proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-13
    See related
    Ensembl:ENSDARG00000042728 AllianceGenome:ZFIN:ZDB-GENE-030826-13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb623; zgc:56568; zgc:66193; wu:fc45d08; wu:fi33e06
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; ovary; pectoral fin musculature; solid lens vesicle; and trigeminal placode. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See plaa in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (61977050..62003834, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (61666888..61693672, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene gametocyte-specific factor 1 Neighboring gene tudor domain containing 7 b Neighboring gene small integral membrane protein 20 Neighboring gene uncharacterized LOC137496236

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of prostaglandin synthesis in ovaries of sexually-mature zebrafish (Danio rerio). Lister AL, et al. Mol Reprod Dev, 2009 Nov. PMID 19551897
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A-2-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212690.1 → NP_997855.1  phospholipase A-2-activating protein

      See identical proteins and their annotated locations for NP_997855.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055539
      UniProtKB/TrEMBL
      Q7SXM2
      Related
      ENSDARP00000062703.4, ENSDART00000062704.5
      Conserved Domains (5) summary
      COG2319
      Location:4 → 303
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:9 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:536 → 791
      PUL; PUL domain
      pfam09070
      Location:346 → 457
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:69 → 110
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      61977050..62003834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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