lrwd1 leucine-rich repeats and WD repeat domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrwd1provided by ZNC
Official Full Name: leucine-rich repeats and WD repeat domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5335
See related: Ensembl:ENSDARG00000035147 AllianceGenome:ZFIN:ZDB-GENE-030131-5335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ORCA; wu:fb78b03; wu:ft31b04; si:dkey-261j4.9
Summary: Predicted to enable chromatin binding activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in chromatin organization and establishment of protein localization to chromatin. Predicted to act upstream of or within DNA replication. Predicted to be located in chromosomal region and nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in blastomere. Orthologous to human LRWD1 (leucine rich repeats and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (61475336..61504876)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (60790632..60820155)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Ndufb11 (e-PCR), detects polymorphism
- UniSTS:498527

fb78b03.x1 (e-PCR)
- UniSTS:191404

fb78b03.x1 (e-PCR)
- UniSTS:191405

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization to chromatin	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to chromatin	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in pericentric heterochromatin	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat and WD repeat-containing protein 1

Names: ORC-associated protein; origin recognition complex-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305662.1 → NP_001292591.1 leucine-rich repeat and WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_001292591.1

Status: VALIDATED

Source sequence(s)

AL935280

UniProtKB/Swiss-Prot

B0R160, Q503J1

UniProtKB/TrEMBL

A0A8M9PX45

Related

ENSDARP00000050905.5, ENSDART00000050906.6

Conserved Domains (4) summary

COG2319
Location:413 → 762

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:504 → 547

7WD40; WD40 repeat [structural motif]

cl42388
Location:43 → 130

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

61475336..61504876

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356041.3 → XP_017211530.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

UniProtKB/Swiss-Prot

B0R160, Q503J1

UniProtKB/TrEMBL

A0A8M9PX45

Conserved Domains (4) summary

COG2319
Location:413 → 762

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:504 → 547

7WD40; WD40 repeat [structural motif]

cl42388
Location:43 → 130

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_678221.9 → XP_683313.4 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A0R4IKV7, A0A8N7T6Y2

Related

ENSDARP00000134872.1, ENSDART00000163444.2

Conserved Domains (5) summary

COG2319
Location:418 → 767

WD40; WD40 repeat [General function prediction only]

sd00033
Location:28 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:52 → 93

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:53 → 107

LRR_8; Leucine rich repeat

sd00039
Location:509 → 552

7WD40; WD40 repeat [structural motif]
XM_021476013.2 → XP_021331688.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2

UniProtKB/Swiss-Prot

B0R160, Q503J1

UniProtKB/TrEMBL

A0A8M9PX45

Conserved Domains (4) summary

COG2319
Location:413 → 762

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:504 → 547

7WD40; WD40 repeat [structural motif]

cl42388
Location:43 → 130

PPP1R42; protein phosphatase 1 regulatory subunit 42