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    srsf3b serine and arginine rich splicing factor 3b [ Danio rerio (zebrafish) ]

    Gene ID: 100145909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srsf3bprovided by ZNC
    Official Full Name
    serine and arginine rich splicing factor 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071005-2
    See related
    Ensembl:ENSDARG00000059360 AllianceGenome:ZFIN:ZDB-GENE-071005-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs3; sfrs3b; wu:fb44e08
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in nuclear speck. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See srsf3b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (613265..623518, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (575542..593549, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene cyclin dependent kinase inhibitor 1A Neighboring gene parathyroid hormone 4 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. Li Z, et al. PLoS One, 2015. PMID 26147004, Free PMC Article
    2. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    3. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. Ritter DI, et al. PLoS One, 2012. PMID 22567096, Free PMC Article
    4. Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. Suarez-Bregua P, et al. FASEB J, 2017 Feb. PMID 28148780, Free PMC Article
    5. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Liu C, et al. Sci Rep, 2015 Jan 29. PMID 25630924, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63887

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 3b
    Names
    splicing factor, arginine/serine-rich 3
    splicing factor, arginine/serine-rich 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309472.1 → NP_001296401.1  serine/arginine-rich splicing factor 3b

      See identical proteins and their annotated locations for NP_001296401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1 Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      EH453768, EH457536, EH562877, EH566262, EH591640
      UniProtKB/TrEMBL
      A0A8M1PJ78, A5WWG4
      Related
      ENSDARP00000119957.1, ENSDART00000135829.3
      Conserved Domains (2) summary
      COG0724
      Location:8 → 92
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:5 → 85
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001309473.1 → NP_001296402.1  serine/arginine-rich splicing factor 3b

      See identical proteins and their annotated locations for NP_001296402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1 Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      EH453768, EH457536, EH562877, EH566262
      UniProtKB/TrEMBL
      A0A8M1PJ78, A5WWG4
      Conserved Domains (2) summary
      COG0724
      Location:8 → 92
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:5 → 85
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_201323.2 → NP_958480.2  serine/arginine-rich splicing factor 3b

      See identical proteins and their annotated locations for NP_958480.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      CU062631, EH453768, EH457536, EH499893, EH562877, EH566262
      UniProtKB/TrEMBL
      A0A8M1PJ78, A5WWG4
      Related
      ENSDARP00000113278.1, ENSDART00000145685.3
      Conserved Domains (2) summary
      COG0724
      Location:8 → 92
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:5 → 85
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      613265..623518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216227.1 → XP_068072328.1  serine/arginine-rich splicing factor 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M1PJ78, A5WWG4
      Related
      ENSDARP00000151665.1, ENSDART00000192778.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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