otx2b orthodenticle homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otx2bprovided by ZNC
Official Full Name: orthodenticle homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-406
See related: Ensembl:ENSDARG00000011235 AllianceGenome:ZFIN:ZDB-GENE-980526-406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: otx2; zOtx2; zotx-2; id:ibd2915; zgc:136535
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; cellular response to alcohol; and retinal pigment epithelium development. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; nervous system; neural keel; neural plate; and presumptive structure. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to human OTX2 (orthodenticle homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (44244659..44249720, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (44130698..44135966, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OTX2 duplications: a recurrent cause of oculo-auriculo-vertebral spectrum.
Title: OTX2 duplications: a recurrent cause of oculo-auriculo-vertebral spectrum.
Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.
Title: Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.
Lbh-like is a new regulator of photoreceptor differentiation directly through modulating otx2 expression in zebrafish.
Title: Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation.
These findings suggest that one or more Otx targets in addition to mitfa and mitfb, possibly another mitf family member, are necessary for development of the retinal pigmented epithelium in zebrafish.
Title: Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.
The Zona limitans intrathalamica is induced within the competence area established by Otx1l/2, and is posteriorly restricted by Irx1b.
Title: Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon.
In vertebrates, the Otx2 promoter acquires multiple, spatiotemporally specific cis-regulators in order to precisely control highly coordinated processes in head development.
Title: Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

otx2 (e-PCR), detects polymorphism
- UniSTS:187013

otx2 (e-PCR), detects polymorphism
- UniSTS:238277

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to alcohol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cerebellum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal pigment epithelium development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein OTX2

Names: etID309955.17; orthodenticle homeobox 2; orthodenticle homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.