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    stx4 syntaxin 4 [ Danio rerio (zebrafish) ]

    Gene ID: 323735, updated on 4-Jan-2025

    Summary

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    Official Symbol
    stx4provided by ZNC
    Official Full Name
    syntaxin 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2455
    See related
    Ensembl:ENSDARG00000052518 AllianceGenome:ZFIN:ZDB-GENE-030131-2455
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    STX4A; zgc:56272; wu:fc08c10; si:dkey-220f10.3
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within detection of mechanical stimulus; response to auditory stimulus; and startle response. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and plasma membrane. Is expressed in cardiac muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human STX4 (syntaxin 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See stx4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20627651..20640165)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (20505777..20518291)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase G Neighboring gene sorting nexin 11 Neighboring gene si:dkey-220f10.4 Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene SNF8 subunit of ESCRT-II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 4 is essential for hearing in human and zebrafish. Schrauwen I, et al. Hum Mol Genet, 2023 Mar 20. PMID 36355422, Free PMC Article
    2. Stx4 is required to regulate cardiomyocyte Ca(2+) handling during vertebrate cardiac development. Perl E, et al. HGG Adv, 2022 Jul 14. PMID 35599850, Free PMC Article
    3. In vivo imaging of molecular interactions at damaged sarcolemma. Roostalu U, et al. Dev Cell, 2012 Mar 13. PMID 22421042
    4. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syntaxin 4 is essential for hearing in human and zebrafish.
      Title: Syntaxin 4 is essential for hearing in human and zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56272

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within detection of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-4
    Names
    syntaxin 4A (placental)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200221.1 → NP_956515.1  syntaxin-4

      See identical proteins and their annotated locations for NP_956515.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046039
      UniProtKB/TrEMBL
      Q6TLF5, Q7ZV18
      Related
      ENSDARP00000068873.4, ENSDART00000074384.5
      Conserved Domains (3) summary
      cd00179
      Location:41 → 190
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15883
      Location:200 → 262
      SNARE_syntaxin4; SNARE motif of syntaxin 4
      pfam00804
      Location:41 → 236
      Syntaxin; Syntaxin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      20627651..20640165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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