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    rpl22l1 ribosomal protein L22-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 735250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpl22l1provided by ZNC
    Official Full Name
    ribosomal protein L22-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060804-3
    See related
    Ensembl:ENSDARG00000010244 AllianceGenome:ZFIN:ZDB-GENE-060804-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa96f07; wu:fa96f07; zgc:136591
    Summary
    Enables pre-mRNA binding activity. Involved in regulation of mRNA cis splicing, via spliceosome. Acts upstream of or within convergent extension involved in axis elongation and definitive hemopoiesis. Is active in nucleus. Is expressed in intermediate cell mass of mesoderm. Orthologous to human RPL22L1 (ribosomal protein L22 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl22l1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26475182..26479835, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26330141..26334794, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene claudin 11b Neighboring gene solute carrier family 7 member 14b Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene TRAF2 and NCK interacting kinase b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Han B, et al. Front Genet, 2020. PMID 33343615, Free PMC Article
    2. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571908, Free PMC Article
    3. A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Rawson A, et al. Pathog Immun, 2022. PMID 35178490, Free PMC Article
    4. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Zhang Y, et al. Dev Cell, 2013 Feb 25. PMID 23449473, Free PMC Article
    5. Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. Wan Y, et al. BMC Med Genomics, 2016 Mar 9. PMID 26961822, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis.
      Title: Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pre-mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within convergent extension involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA cis splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein eL22-like
    NP_001038800.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045335.2 → NP_001038800.1  ribosomal protein eL22-like

      See identical proteins and their annotated locations for NP_001038800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      BC118681, EH565022
      UniProtKB/TrEMBL
      A0A8M1NAG4, Q0VFW0
      Related
      ENSDARP00000074434.5, ENSDART00000079984.7
      Conserved Domains (1) summary
      pfam01776
      Location:18 → 120
      Ribosomal_L22e; Ribosomal L22e protein family

    RNA

    1. NR_027625.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC118681, BC122324, CR354583
      Related
      ENSDART00000136871.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      26475182..26479835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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