prph2b peripherin 2b (retinal degeneration, slow) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prph2bprovided by ZNC
Official Full Name: peripherin 2b (retinal degeneration, slow)provided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-9
See related: Ensembl:ENSDARG00000014840 AllianceGenome:ZFIN:ZDB-GENE-000616-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rds4
Summary: Predicted to be involved in protein localization to plasma membrane and protein maturation. Predicted to act upstream of or within visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (3252950..3258773)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (3119600..3125423)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peripherin-2b

Names: retinal degradation slow 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131567.1 → NP_571642.1 peripherin-2b

See identical proteins and their annotated locations for NP_571642.1

Status: PROVISIONAL

Source sequence(s)

BC059645

UniProtKB/TrEMBL

A0A2R8QGF1, A9JR63, Q6PBN3

Related

ENSDARP00000011326.8, ENSDART00000020671.9

Conserved Domains (2) summary

cd03162
Location:120 → 262

peripherin_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:20 → 279

Tetraspannin; Tetraspanin family