U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nedd4l NEDD4 like E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 559634, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nedd4lprovided by ZNC
    Official Full Name
    NEDD4 like E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051118-2
    See related
    Ensembl:ENSDARG00000060006 AllianceGenome:ZFIN:ZDB-GENE-051118-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nedd4l in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (10889152..11054876, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (10796524..10962280, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100536431 Neighboring gene microRNA 122 Neighboring gene prolactin receptor a Neighboring gene alanine--glyoxylate aminotransferase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Bakkers J, et al. Cell Cycle, 2005 Jun. PMID 15908775
    2. Itch is required for lateral line development in zebrafish. Angers A, et al. PLoS One, 2014. PMID 25369329, Free PMC Article
    3. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Sander JD, et al. Nat Methods, 2011 Jan. PMID 21151135, Free PMC Article
    4. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like
    Names
    nedd4b
    XP_005161144.1
    XP_021324693.1
    XP_021324694.1
    XP_068072101.1
    XP_068072102.1
    XP_068072103.1
    XP_068072104.1
    XP_068072105.1
    XP_068072106.1
    XP_068072107.1
    XP_068072108.1
    XP_068072109.1
    XP_068072110.1
    XP_068072111.1
    XP_688089.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      10889152..11054876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682997.8 → XP_688089.3  E3 ubiquitin-protein ligase NEDD4-like isoform X15

      UniProtKB/TrEMBL
      A0A8M9PUG8, A0A8N7UQV5
      Related
      ENSDARP00000117300.1, ENSDART00000146576.3
      Conserved Domains (5) summary
      cd04033
      Location:20 → 152
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:568 → 600
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:661 → 990
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:637 → 991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:390 → 419
      WW; WW domain

    2. XM_068216010.1 → XP_068072111.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

      UniProtKB/TrEMBL
      A0A8M9PUG8

    3. XM_005161087.3 → XP_005161144.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      UniProtKB/TrEMBL
      A0A8M2B803, A0A8M9PIS2
      Conserved Domains (5) summary
      cd04033
      Location:20 → 152
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:570 → 602
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:663 → 992
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:639 → 993
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:391 → 420
      WW; WW domain

    4. XM_068216009.1 → XP_068072110.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      UniProtKB/TrEMBL
      A0A8M9PD44
      Related
      ENSDARP00000078496.4, ENSDART00000084061.7

    5. XM_068216008.1 → XP_068072109.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      UniProtKB/TrEMBL
      A0A8M9PD44

    6. XM_068216007.1 → XP_068072108.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8M9PD44

    7. XM_068216004.1 → XP_068072105.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8M9PUG3

    8. XM_068216006.1 → XP_068072107.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      A0A8M9P3M5

    9. XM_068216003.1 → XP_068072104.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A8M9P3M1

    10. XM_068216001.1 → XP_068072102.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      UniProtKB/TrEMBL
      A0A8M9PUF7

    11. XM_068216005.1 → XP_068072106.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      UniProtKB/TrEMBL
      A0A8M9PQY1

    12. XM_068216002.1 → XP_068072103.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      UniProtKB/TrEMBL
      A0A8M9PQX6

    13. XM_068216000.1 → XP_068072101.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      UniProtKB/TrEMBL
      A0A8M9PD36

    14. XM_021469019.2 → XP_021324694.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      UniProtKB/TrEMBL
      A0A8M9PIR5, A0A8M9PIR9
      Conserved Domains (4) summary
      smart00456
      Location:847 → 879
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:940 → 1269
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:669 → 698
      WW; WW domain
      cl14603
      Location:374 → 430
      C2; C2 domain

    15. XM_021469018.2 → XP_021324693.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9P3L7, A0A8M9PD40
      Conserved Domains (4) summary
      smart00456
      Location:848 → 880
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:941 → 1270
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:669 → 698
      WW; WW domain
      cl14603
      Location:374 → 430
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools