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    hspa4l heat shock protein 4 like [ Danio rerio (zebrafish) ]

    Gene ID: 562019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hspa4lprovided by ZNC
    Official Full Name
    heat shock protein 4 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2412
    See related
    Ensembl:ENSDARG00000053544 AllianceGenome:ZFIN:ZDB-GENE-030131-2412
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc07b10; wu:fc07b10; si:dkey-21a6.6
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system and lens. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hspa4l in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43431020..43466288, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43439825..43475755, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene inositol-tetrakisphosphate 1-kinase b Neighboring gene polo-like kinase 4 (Drosophila) Neighboring gene charged multivesicular body protein 3 Neighboring gene receptor accessory protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Khan SY, et al. Nat Commun, 2016 Apr 6. PMID 27218149, Free PMC Article
    2. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Gong L, et al. Cell Rep, 2019 Dec 10. PMID 31825845
    3. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
    4. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article
    5. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease in zebrafish. Sarath Babu N, et al. Proteomics, 2016 May. PMID 26959078

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 4L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      43431020..43466288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685413.9 → XP_690505.2  heat shock 70 kDa protein 4L

      UniProtKB/TrEMBL
      A0A8N7T7F2, X1WBR5
      Related
      ENSDARP00000127657.1, ENSDART00000155313.2
      Conserved Domains (2) summary
      pfam00012
      Location:3 → 686
      HSP70; Hsp70 protein
      cl17037
      Location:2 → 384
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version

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