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    ctnnd1 catenin (cadherin-associated protein), delta 1 [ Danio rerio (zebrafish) ]

    Gene ID: 556726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctnnd1provided by ZNC
    Official Full Name
    catenin (cadherin-associated protein), delta 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110208-9
    See related
    Ensembl:ENSDARG00000078233 AllianceGenome:ZFIN:ZDB-GENE-110208-9
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable cadherin binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; mesodermal cell migration; and posterior lateral line neuromast primordium migration. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ctnnd1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (44173249..44229065)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (43471891..43527579)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene prostaglandin D2 receptor 2 Neighboring gene calcium binding protein 2a Neighboring gene solute carrier family 43 member 3a Neighboring gene uncharacterized LOC137495318 Neighboring gene serine/threonine-protein kinase pim-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of serine residues S252, S268/S269, and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos. Kupai A, et al. Dev Dyn, 2022 Dec. PMID 35706088
    2. Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation. Shan B, et al. Dev Dyn, 2022 Dec. PMID 35996230
    3. Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Mizoguchi T, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078376, Free PMC Article
    4. ZebraShare: a new venue for rapid dissemination of zebrafish mutant data. DeLaurier A, et al. PeerJ, 2021. PMID 33954026, Free PMC Article
    5. Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. Hsu CL, et al. Dev Dyn, 2012 Oct. PMID 22911626

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line neuromast primordium migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catenin delta-1
    Names
    catenin, delta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      44173249..44229065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293418.4 → XP_009291693.1  catenin delta-1 isoform X3

      See identical proteins and their annotated locations for XP_009291693.1

      UniProtKB/TrEMBL
      A0A286Y8C1, A0A8M3ART0
      Related
      ENSDARP00000143408.2, ENSDART00000179560.2
      Conserved Domains (3) summary
      cd00020
      Location:351 → 469
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]
      cl23782
      Location:140 → 214
      RCR; Chitin synthesis regulation, resistance to Congo red

    2. XM_021476934.2 → XP_021332609.1  catenin delta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q686
      Conserved Domains (3) summary
      smart00185
      Location:428 → 469
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:385 → 424
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]

    3. XM_009293431.4 → XP_009291706.1  catenin delta-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AK93
      Conserved Domains (3) summary
      cd00020
      Location:351 → 469
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]
      cl23782
      Location:140 → 214
      RCR; Chitin synthesis regulation, resistance to Congo red

    4. XM_068221586.1 → XP_068077687.1  catenin delta-1 isoform X4

    5. XM_021476938.2 → XP_021332613.1  catenin delta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PZY3
      Conserved Domains (3) summary
      smart00185
      Location:428 → 469
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:385 → 424
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]

    6. XM_009293437.4 → XP_009291712.1  catenin delta-1 isoform X6

      UniProtKB/TrEMBL
      A0A0R4IV39, A0A8M3B2S3, F1R6C8
      Related
      ENSDARP00000096826.3, ENSDART00000106048.4
      Conserved Domains (3) summary
      cd00020
      Location:351 → 469
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]
      cl23782
      Location:140 → 214
      RCR; Chitin synthesis regulation, resistance to Congo red

    7. XM_021476943.2 → XP_021332618.1  catenin delta-1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9Q693
      Conserved Domains (3) summary
      smart00185
      Location:353 → 394
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:310 → 349
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:281 → 306
      ARM; armadillo repeat [structural motif]

    8. XM_068221590.1 → XP_068077691.1  catenin delta-1 isoform X10

    9. XM_068221592.1 → XP_068077693.1  catenin delta-1 isoform X11

    10. XM_021476936.2 → XP_021332611.1  catenin delta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q686
      Conserved Domains (3) summary
      smart00185
      Location:428 → 469
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:385 → 424
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:356 → 381
      ARM; armadillo repeat [structural motif]

    11. XM_068221587.1 → XP_068077688.1  catenin delta-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AK93

    12. XM_021476944.2 → XP_021332619.1  catenin delta-1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9Q693
      Conserved Domains (3) summary
      smart00185
      Location:353 → 394
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:310 → 349
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:281 → 306
      ARM; armadillo repeat [structural motif]

    13. XM_068221591.1 → XP_068077692.1  catenin delta-1 isoform X10

    14. XM_068221589.1 → XP_068077690.1  catenin delta-1 isoform X9

    15. XM_068221588.1 → XP_068077689.1  catenin delta-1 isoform X8

    Nucleotide Protein
    Heading Accession and Version

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