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    ctss2.2 cathepsin S, ortholog 2, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 337572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctss2.2provided by ZNC
    Official Full Name
    cathepsin S, ortholog 2, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050626-55
    See related
    Ensembl:ENSDARG00000013771 AllianceGenome:ZFIN:ZDB-GENE-050626-55
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ctssb2; ctssb.2; wu:fj84d06; zgc:111950; zgc:112489
    Summary
    Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region and phagocytic vesicle. Predicted to be active in extracellular space and lysosome. Is expressed in blood; macrophage; and yolk syncytial layer. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ctss2.2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29514496..29519964)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29579873..29585426)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cathepsin K Neighboring gene cathepsin S, ortholog2, tandem duplicate 1 Neighboring gene one cut domain, family member, like Neighboring gene HORMA domain containing 1 Neighboring gene endosulfine alpha b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge. Dong X, et al. Fish Shellfish Immunol, 2016 Jan. PMID 26626584
    2. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Tingaud-Sequeira A, et al. Gene, 2007 Jan 15. PMID 17027199
    3. Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates. Zhou J, et al. Int J Biol Sci, 2015. PMID 26221069, Free PMC Article
    4. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Wu XM, et al. Front Immunol, 2018. PMID 29692779, Free PMC Article
    5. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Chernyavskaya Y, et al. Development, 2017 Aug 15. PMID 28698226, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin S, ortholog 2, tandem duplicate 2
    Names
    cathepsin S, b.2
    cathepsin Sb, tandem duplicate 2
    NP_001017661.1
    XP_009290599.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017661.1 → NP_001017661.1  cathepsin S, ortholog 2, tandem duplicate 2 precursor

      See identical proteins and their annotated locations for NP_001017661.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093339
      UniProtKB/TrEMBL
      Q566T8
      Related
      ENSDARP00000034094.6, ENSDART00000034102.7
      Conserved Domains (2) summary
      smart00848
      Location:27 → 86
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:115 → 329
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29514496..29519964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292324.4 → XP_009290599.1  cathepsin S, ortholog 2, tandem duplicate 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATF0
      Related
      ENSDARP00000143447.2, ENSDART00000174895.2
      Conserved Domains (2) summary
      smart00848
      Location:34 → 93
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:122 → 336
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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