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    rangap1b Ran GTPase activating protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 568424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rangap1bprovided by ZNC
    Official Full Name
    Ran GTPase activating protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1921
    See related
    Ensembl:ENSDARG00000056059 AllianceGenome:ZFIN:ZDB-GENE-040426-1921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rangap1; zgc:66165; wu:fj57h07
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in nuclear export. Predicted to act upstream of or within signal transduction. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rangap1b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19007925..19028068, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18886051..18906194, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene chondroadherin-like b Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene phospholipase B domain containing 1b Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene guanylate cyclase 2Cb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66165, MGC174778

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ran GTPase-activating protein 1b
    Names
    Ran GTPase activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212989.2 → NP_998154.2  ran GTPase-activating protein 1b

      Status: VALIDATED

      Source sequence(s)
      BI884738, BM184899, CR450737
      UniProtKB/TrEMBL
      A0A8M2B322, A9JTA8
      Related
      ENSDARP00000072946.5, ENSDART00000078484.7
      Conserved Domains (3) summary
      cd00116
      Location:31 → 346
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:396 → 570
      RanGAP1_C; RanGAP1 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      19007925..19028068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156154.5 → XP_005156211.1  ran GTPase-activating protein 1b isoform X1

      See identical proteins and their annotated locations for XP_005156211.1

      UniProtKB/TrEMBL
      A0A8M2B322, A9JTA8
      Conserved Domains (3) summary
      cd00116
      Location:31 → 346
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:51 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07834
      Location:396 → 570
      RanGAP1_C; RanGAP1 C-terminal domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      227594..246918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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