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    ptpn3 protein tyrosine phosphatase non-receptor type 3 [ Danio rerio (zebrafish) ]

    Gene ID: 407635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptpn3provided by ZNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2934
    See related
    Ensembl:ENSDARG00000055784 AllianceGenome:ZFIN:ZDB-GENE-030131-2934
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc21h03; wu:fc21h03
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in developmental process. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in liver. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ptpn3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26547221..26600625)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26673543..26727181)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 1b Neighboring gene serum/glucocorticoid regulated kinase 2b Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC137487907 Neighboring gene epithelial splicing regulatory protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Studzinski AL, et al. Gen Comp Endocrinol, 2009 Mar. PMID 18955058
    2. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
    3. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
    4. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 3
    Names
    PTP-H1
    protein tyrosine phosphatase H1
    XP_687930.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      26547221..26600625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682838.10 → XP_687930.5  tyrosine-protein phosphatase non-receptor type 3

      UniProtKB/TrEMBL
      A0A8N7UQV2, F1QLN8
      Related
      ENSDARP00000118507.1, ENSDART00000141393.2
      Conserved Domains (7) summary
      smart00194
      Location:579 → 829
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:33 → 223
      B41; Band 4.1 homologues
      cd00047
      Location:602 → 828
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:439 → 526
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:117 → 223
      FERM_M; FERM central domain
      pfam09379
      Location:35 → 98
      FERM_N; FERM N-terminal domain
      cl17171
      Location:217 → 309
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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