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    recql5 RecQ helicase-like 5 [ Danio rerio (zebrafish) ]

    Gene ID: 566553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    recql5provided by ZNC
    Official Full Name
    RecQ helicase-like 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071214-1
    See related
    Ensembl:ENSDARG00000059556 AllianceGenome:ZFIN:ZDB-GENE-071214-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    recql5l
    Summary
    Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Acts upstream of or within negative regulation of mitotic recombination. Predicted to be located in nucleus. Predicted to be active in chromosome and cytoplasm. Is expressed in several structures, including otic vesicle; pericardial region; presumptive neural retina; retina; and ventricular system. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See recql5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (59986120..60027334, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (59695019..59736237, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene uncharacterized LOC137490783 Neighboring gene si:ch211-110e21.3 Neighboring gene si:ch211-110e21.4 Neighboring gene uncharacterized LOC137490784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Xie J, et al. Genetics, 2007 Jun. PMID 17483412, Free PMC Article
    2. Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Annus T, et al. Cell Death Dis, 2022 Apr 18. PMID 35436990, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase Q5
    Names
    RecQ protein-like 5 like
    XP_005164331.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      59986120..60027334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164274.5 → XP_005164331.1  ATP-dependent DNA helicase Q5

      UniProtKB/TrEMBL
      A0A8M2BBK2, X1WCM8
      Related
      ENSDARP00000127973.1, ENSDART00000154684.2
      Conserved Domains (5) summary
      smart00487
      Location:12 → 217
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:211 → 347
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:22 → 189
      DEAD; DEAD/DEAH box helicase
      pfam06959
      Location:629 → 755
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:352 → 420
      RecQ_Zn_bind; RecQ zinc-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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