ccna2 cyclin A2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccna2provided by ZNC
Official Full Name: cyclin A2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020418-1
See related: Ensembl:ENSDARG00000011094 AllianceGenome:ZFIN:ZDB-GENE-020418-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CycA2; cb671; chunp6924; wu:fi36f03
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in several structures, including nervous system; neural tube; pectoral fin musculature; primordial germ cell; and tail bud. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (46357828..46374649, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (47357468..47387568, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an essential role for UHRF1 phosphorylation by cyclin-dependent kinase 2/cyclin A2 during early vertebrate development
Title: UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fj82d04.x1 (e-PCR)
- UniSTS:200023

fe49e07.x1 (e-PCR)
- UniSTS:196551

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin A2-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152949.1 → NP_694481.1 cyclin-A2

See identical proteins and their annotated locations for NP_694481.1

Status: PROVISIONAL

Source sequence(s)

AF234784

UniProtKB/TrEMBL

F1R0L6, Q6NV43, Q7ZVJ2, Q98TA3

Related

ENSDARP00000029094.6, ENSDART00000031498.8

Conserved Domains (3) summary

pfam00134
Location:177 → 303

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:305 → 422

Cyclin_C; Cyclin, C-terminal domain

pfam16500
Location:33 → 157

Cyclin_N2; N-terminal region of cyclin_N