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    stk25b serine/threonine kinase 25b [ Danio rerio (zebrafish) ]

    Gene ID: 406600, updated on 27-Dec-2024

    Summary

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    Official Symbol
    stk25bprovided by ZNC
    Official Full Name
    serine/threonine kinase 25bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2537
    See related
    Ensembl:ENSDARG00000039022 AllianceGenome:ZFIN:ZDB-GENE-040426-2537
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    stk25; zgc:56022; zgc:77029
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within blood vessel morphogenesis and heart development. Predicted to be located in cytoplasm. Is expressed in blastomere; brain; head; and post-vent region. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stk25b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22617671..22636689, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (22962020..22981060, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transcription factor Sox-14 Neighboring gene septin 2 Neighboring gene BCL2 family apoptosis regulator BOK b Neighboring gene THAP domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Yoruk B, et al. Dev Biol, 2012 Feb 15. PMID 22182521
    2. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. Zheng X, et al. J Clin Invest, 2010 Aug. PMID 20592472, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 25
    Names
    novel serine/threonine kinase protein (zgc:77029)
    serine/threonine kinase 25 (STE20 homolog, yeast)
    stk25a
    NP_998473.1
    XP_005171260.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213308.1 → NP_998473.1  serine/threonine-protein kinase 25

      See identical proteins and their annotated locations for NP_998473.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066512
      UniProtKB/TrEMBL
      B2GQG6, F6NU64, Q7ZVG8
      Related
      ENSDARP00000056962.6, ENSDART00000056963.8
      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:20 → 291
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      22617671..22636689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171203.5 → XP_005171260.1  serine/threonine-protein kinase 25 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BII7
      Conserved Domains (2) summary
      smart00220
      Location:20 → 270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:20 → 291
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version

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