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    eif2s1a eukaryotic translation initiation factor 2, subunit 1 alpha a [ Danio rerio (zebrafish) ]

    Gene ID: 321807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif2s1aprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 1 alpha aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-526
    See related
    Ensembl:ENSDARG00000005827 AllianceGenome:ZFIN:ZDB-GENE-030131-526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Eif2s1; eif2s1l; fb36a08; zgc:56510; wu:fb36a08
    Summary
    Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 48S preinitiation complex and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eif2s1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (34244345..34254233)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (34296399..34306287)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909052 Neighboring gene gephyrin a Neighboring gene protein associated with LIN7 1, MAGUK p55 family member a Neighboring gene uncharacterized LOC137488124 Neighboring gene uncharacterized LOC103909053 Neighboring gene uncharacterized LOC137488125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and functional analysis of PKR from grass carp (Ctenopharyngodon idellus). Hu YS, et al. Fish Shellfish Immunol, 2013 Dec. PMID 24084043
    2. Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. Rothenburg S, et al. BMC Microbiol, 2011 Mar 18. PMID 21418572, Free PMC Article
    3. Triclocarban at environmentally relevant concentrations induces the endoplasmic reticulum stress in zebrafish. Zhou T, et al. Environ Toxicol, 2019 Mar. PMID 30592132
    4. N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes. Zhao S, et al. Chemosphere, 2018 Aug. PMID 29679867
    5. Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. Crouzier L, et al. Int J Mol Sci, 2021 Oct 13. PMID 34681705, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1a
    Names
    eukaryotic translation initiation factor 2, subunit 1 alpha, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199569.1 → NP_955863.1  eukaryotic translation initiation factor 2 subunit 1a

      See identical proteins and their annotated locations for NP_955863.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049468
      UniProtKB/TrEMBL
      Q6P134, Q7ZWD3
      Related
      ENSDARP00000026560.8, ENSDART00000006058.9
      Conserved Domains (3) summary
      cd04452
      Location:14 → 89
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      PTZ00248
      Location:4 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
      pfam07541
      Location:131 → 241
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      34244345..34254233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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