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    pole2 polymerase (DNA directed), epsilon 2 [ Danio rerio (zebrafish) ]

    Gene ID: 192320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pole2provided by ZNC
    Official Full Name
    polymerase (DNA directed), epsilon 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-16
    See related
    AllianceGenome:ZFIN:ZDB-GENE-020419-16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CHUNP6886; wu:fb49c03; wu:fc49h08
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA-templated DNA replication and error-prone translesion synthesis. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Is expressed in several structures, including eye; immature eye; intestinal bulb primordium; neural plate; and ventricular zone. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See pole2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (81101..89361, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (116836..122584, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487347 Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene stonin 1 Neighboring gene kelch domain-containing protein 1 Neighboring gene uncharacterized LOC101883147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon subunit 2
    Names
    epsilon 2
    NP_775353.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173246.1 → NP_775353.1  DNA polymerase epsilon subunit 2

      See identical proteins and their annotated locations for NP_775353.1

      Status: PROVISIONAL

      Source sequence(s)
      AF506228
      UniProtKB/TrEMBL
      Q8JHG8
      Conserved Domains (3) summary
      pfam04042
      Location:288 → 487
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam04598
      Location:2 → 161
      Gasdermin; Gasdermin family
      pfam12213
      Location:3 → 73
      Dpoe2NT; DNA polymerases epsilon N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      81101..89361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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