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    babam2 BRISC and BRCA1 A complex member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 550474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    babam2provided by ZNC
    Official Full Name
    BRISC and BRCA1 A complex member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-299
    See related
    Ensembl:ENSDARG00000038863 AllianceGenome:ZFIN:ZDB-GENE-050417-299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bre; im:7141046; zgc:110368
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleus. Predicted to be part of BRCA1-A complex and BRISC complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See babam2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (41081997..41264361)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (41126686..41309449)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene ribokinase Neighboring gene uncharacterized LOC101885155 Neighboring gene FOS like 2, AP-1 transcription factor subunit Neighboring gene molybdenum cofactor synthesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. Kubra K, et al. Int J Mol Sci, 2022 Sep 3. PMID 36077499, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BRCA1-A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of BRISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BRISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    BRISC and BRCA1-A complex member 2
    Names
    BRCA1-A complex subunit BRE
    BRCA1/BRCA2-containing complex subunit 45
    brain and reproductive organ-expressed protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017777.1 → NP_001017777.1  BRISC and BRCA1-A complex member 2

      See identical proteins and their annotated locations for NP_001017777.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092902
      UniProtKB/Swiss-Prot
      Q568D5
      Related
      ENSDARP00000056741.5, ENSDART00000056742.8
      Conserved Domains (1) summary
      pfam06113
      Location:11 → 336
      BRE; Brain and reproductive organ-expressed protein (BRE)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      41081997..41264361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467158.2 → XP_021322833.1  BRISC and BRCA1-A complex member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P8W4
      Conserved Domains (1) summary
      pfam06113
      Location:11 → 336
      BRE; Brain and reproductive organ-expressed protein (BRE)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q568D5.1 GenPept UniProtKB/Swiss-Prot:Q568D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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