pcsk1nl proprotein convertase subtilisin/kexin type 1 inhibitor, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcsk1nlprovided by ZNC
Official Full Name: proprotein convertase subtilisin/kexin type 1 inhibitor, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090427-2
See related: Ensembl:ENSDARG00000076170 AllianceGenome:ZFIN:ZDB-GENE-090427-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: uo:ion003; wu:fj32g06
Summary: Enables serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of endopeptidase activity. Is expressed in adenohypophyseal placode; nervous system; and pancreas. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (7359292..7379391)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (7340561..7360660)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both zebrafish and Xenopus proSAAS exhibited neural and endocrine distributions.
Title: Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences.

Submit: New GeneRIF Correction

General gene information

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Markers

fj32g06.x1 (e-PCR)
- UniSTS:199084

fi67a02.y1 (e-PCR)
- UniSTS:197828

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proprotein convertase subtilisin/kexin type 1 inhibitor, like

Names: proSAAS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166129.1 → NP_001159601.1 proprotein convertase subtilisin/kexin type 1 inhibitor, like precursor

Status: VALIDATED

Source sequence(s)

BX469901

UniProtKB/TrEMBL

A0A8M1NSU7, F1QCH5

Related

ENSDARP00000109911.2, ENSDART00000121708.3