aqp1a.1 aquaporin 1a (Colton blood group), tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aqp1a.1provided by ZNC
Official Full Name: aquaporin 1a (Colton blood group), tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7764
See related: Ensembl:ENSDARG00000023713 AllianceGenome:ZFIN:ZDB-GENE-030131-7764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj33g04; zgc:85890; wu:fj33g04
Summary: Enables ammonium channel activity; carbon dioxide transmembrane transporter activity; and water channel activity. Acts upstream of or within ammonium transmembrane transport; carbon dioxide transport; and proton export across plasma membrane. Predicted to be located in membrane. Is expressed in several structures, including blood cell; cardiovascular system; ionocyte; mesoderm; and pleuroperitoneal region. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (2737567..2749219)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (2895668..2907320)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AQP1a1 in zebrafish larvae facilitates the movement of CO2 and ammonia, as well as water, in a physiologically relevant fashion.
Title: The water channel aquaporin-1a1 facilitates movement of CO₂ and ammonia in zebrafish (Danio rerio) larvae.
In situ hybridization and immunohistochemistry showed that the AQP1a.1 transcript was highly expressed by acid-secreting ionocytes.
Title: Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport.
water movement can occur through transcellular routes (via AQP); the paracellular routes may become significant when the paracellular permeability is increased
Title: The role of aquaporin and tight junction proteins in the regulation of water movement in larval zebrafish (Danio rerio).
endogenous aqp1a expression was observed in both primitive and definitive hematopoietic erythroid progenitors, in the otic vesicle, swim bladder, pneumatic duct, intestine and a subset of neurons within the retina and the midbrain-hindbrain region.
Title: Zebrafish enhancer trap line recapitulates embryonic aquaporin 1a expression pattern in vascular endothelial cells.
Compared with human AQP1, zebrafish Aqp1a has about twice the selectivity for CO(2) over NH(3).
Title: Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables carbon dioxide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbon dioxide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ammonium transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbon dioxide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within carbon dioxide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aquaporin-1a.1

Names: Aqp1aa; aqp1a; aquaporin 1; aquaporin 1a, tandem duplicate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.